Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.56 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GABRP | O00591 | 2/20 | 0.36 |
| ▸ | GABRD | O14764 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL63722 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL6227317 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL382027 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL30947437 | 0.92 | LMNA (0.53) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL15346029 | 0.92 | TSHR (0.47) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL15346031 | 0.92 | TSHR (0.47) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL1398344 | 0.89 | TSHR (0.45) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL28453291 | 0.89 | TSHR (0.45) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL7903195 | 0.89 | TSHR (0.45) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL28265770 | 0.89 | TSHR (0.45) | TSHRTP53EGLN1EGLN3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 310 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109422846-B | Polymethyl methacrylate-maleic acid fatty alcohol ester sodium salt-silver nano composite material and preparation method thereof | 天津大学 | 2020-12-29 | — | — | CN | claimed |
| CN-109422847-B | Polymethyl methacrylate-sodium salt of fatty alcohol ester of maleic acid-aluminum oxide nano composite material and preparation method thereof | 天津大学 | 2020-12-29 | — | — | CN | claimed |
| CN-109422847-A | Polymethyl methacrylate-maleic acid fatty alcohol ester sodium salt-aluminum oxide nanocomposite and preparation method thereof | 天津大学 | 2019-03-05 | — | — | CN | claimed |
| CN-109422846-A | Polymethyl methacrylate-maleic acid fatty alcohol ester sodium salt-argentum nano composite material and preparation method thereof | 天津大学 | 2019-03-05 | — | — | CN | claimed |
| CN-106065039-B | Preparation method of water-soluble antibacterial acrylic polymer silver salt | 王式禹 | 2018-11-13 | — | — | CN | claimed |
| CN-108290377-A | GAS BARRIER FILM AND ELECTRONIC DEVICE | 柯尼卡美能达株式会社 | 2018-07-17 | — | — | CN | claimed |
| CN-107720986-A | A kind of alkali hard water softening agent | 南京巨鲨显示科技有限公司 | 2018-02-23 | — | — | CN | claimed |
| CN-106065039-A | Preparation method of water-soluble antibacterial acrylic polymer silver salt | 王式禹 | 2016-11-02 | — | — | CN | claimed |
| US-5391452-A | Polyester toner and developer compositions | XEROX CORPORATION (US) | 1995-02-21 | — | — | US | claimed |
| EP-0592907-A1 | Pigment compositions for solvent and water-based ink systems and the methods for producing them | HOECHST CELANESE CORPORATION (US) | 1994-04-20 | — | — | EP | claimed |
| US-5298535-A | Monoazo and disazo pigments dispersed in metal salt of carboxylic acid polymer | HOECHST CELANESE CORPORATION (US) | 1994-03-29 | — | — | US | claimed |
| US-4970011-A | ANIONIC CPOLYMER DISPERSANTS, POLYOXYETHYLENE SURFACTANTS | KAO SOAP COMPANY, LTD. (JP) | 1990-11-13 | — | — | US | claimed |
| US-4886725-A | Toner composition containing organotin oxide | CANON KABUSHIKI KAISHA (JP) | 1989-12-12 | — | — | US | claimed |
| EP-0235961-A1 | Scratch inhibiting agent | LION CORPORATION (JP) | 1987-09-09 | — | — | EP | claimed |
| US-3991226-A | Method of creating an image using hybrid liquid toners | PHILIP A. HUNT CHEMICAL CORPORATION (US) | 1976-11-09 | — | — | US | claimed |
| CN-117327315-A | Laminate body | 富士胶片株式会社 | 2024-01-02 | — | — | CN | disclosed |
| WO-2023228934-A1 | LIQUID AGROCHEMICAL COMPOSITION | 住友化学株式会社 | 2023-11-30 | — | — | WO | disclosed |
| US-4598125-A | Preparation of impact-resistant nylon molding materials by alkaline lactam polymerization | BASF AKTIENGELLSCHAFT (DE) | 1986-07-01 | — | — | US | disclosed |
| EP-0063561-A1 | CROSS-LINKED HYDROPHILIC POLYMERS. | PATEL PRAVIN GORDHANBHAI (GB) | 1982-11-03 | — | — | EP | disclosed |
| WO-1982001553-A1 | CROSS-LINKED HYDROPHILIC POLYMERS | PATEL PRAVIN | 1982-05-13 | — | — | WO | disclosed |