Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 11/20 | 0.48 |
| ▸ | RORC | P51449 | 4/20 | 0.48 |
| ▸ | THRA | P10827 | 7/20 | 0.42 |
| ▸ | ERN1 | O75460 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12312519 | 0.84 | THRB (0.49) | TUBB1THRBRORCTHRA | |
| SCHEMBL29965444 | 0.83 | TUBB1 (0.48) | TUBB1THRBRORCTHRAERN1 | |
| SCHEMBL23663122 | 0.83 | TUBB1 (0.48) | TUBB1THRBRORCTHRAERN1 | |
| SCHEMBL7039684 | 0.80 | TUBB1 (0.45) | TUBB1THRBRORCERN1CYP1A2 | |
| SCHEMBL4961567 | 0.79 | TLR9 (0.49) | TUBB1THRBRORCERN1CYP1A2 | |
| SCHEMBL6367633 | 0.79 | THRB (0.50) | THRBRORCTHRAALDH1A1KDM4E | |
| SCHEMBL6366915 | 0.77 | THRB (0.49) | THRBRORCTHRA | |
| SCHEMBL31287740 | 0.76 | TUBB1 (0.49) | TUBB1ERN1CYP1A2ALDH1A1KDM4E | |
| SCHEMBL11123319 | 0.74 | ALDH1A1 (0.53) | TUBB1ERN1CYP1A2ALDH1A1KDM4E | |
| SCHEMBL6693303 | 0.73 | TUBB1 (0.46) | TUBB1ERN1CYP1A2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6960604-B2 | Thyroid receptor ligands | PFIZER INC. (US) | 2005-11-01 | — | — | US | disclosed |
| US-20040110951-A1 | Thyroid receptor ligands | CHIANG YUAN-CHING P (US) | 2004-06-10 | — | — | US | disclosed |
| US-6620830-B2 | Certain thiazolidinedione, oxadiazolidinedione, and triazolone compounds which are thyroid receptor ligands | PFIZER, INC. | 2003-09-16 | — | — | US | disclosed |
| US-20010051645-A1 | Thyroid receptor ligands | CHIANG YUAN-CHING P (US) | 2001-12-13 | — | — | US | disclosed |
| EP-1148054-A1 | Thyroid receptor ligands | Pfizer Products Inc. (US) | 2001-10-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010051645-A1 | Thyroid receptor ligands | TSHR, THRB, THRA | TUBB1 2866/4885THRB 2/4885RORC 302/4885 |
| US-20040110951-A1 | Thyroid receptor ligands | TSHR, THRB, THRA | TUBB1 2866/4885THRB 2/4885RORC 302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.