SCHEMBL637495

SCHEMBL637495

Cc1ccccc1C(OCCN(C)Cl)c1ccccc1

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 6/20 0.78
SLC6A4 P31645 6/20 0.78
SLC6A3 Q01959 6/20 0.78
CYP2D6 P10635 3/20 0.78
CHRM2 P08172 3/20 0.78
ADRA2A P08913 3/20 0.78
CHRM1 P11229 3/20 0.78
OPRM1 P35372 3/20 0.78
DRD3 P35462 3/20 0.78
CHRM4 P08173 2/20 0.78
CHRM5 P08912 2/20 0.78
ADRA2B P18089 2/20 0.78
CHRM3 P20309 2/20 0.78
HRH2 P25021 2/20 0.78
HTR2A P28223 2/20 0.78
HTR2C P28335 2/20 0.78
ADRA1A P35348 2/20 0.78
HRH1 P35367 2/20 0.78
HTR2B P41595 2/20 0.78
HTR6 P50406 2/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Orphenadrine SCHEMBL119471 0.88 SLC6A2 (1.00) SLC6A2SLC6A4SLC6A3CYP2D6CHRM2
Orphenadrine SCHEMBL29359844 0.88 SLC6A2 (1.00) SLC6A2SLC6A4SLC6A3CYP2D6CHRM2
Orphenadrine SCHEMBL28727 0.88 SLC6A2 (1.00) SLC6A2SLC6A4SLC6A3CYP2D6CHRM2
Orphenadrine SCHEMBL30903909 0.87 LMNA (1.00) SLC6A2SLC6A4SLC6A3CYP2D6CHRM2
Orphenadrine SCHEMBL1235378 0.87 LMNA (1.00) SLC6A2SLC6A4SLC6A3CYP2D6CHRM2
SCHEMBL16349409 0.86 SLC6A2 (0.73) SLC6A2SLC6A4SLC6A3CYP2D6CHRM2
Orphenadrine SCHEMBL4338150 0.85 SLC6A2 (0.94) SLC6A2SLC6A4SLC6A3CYP2D6CHRM2
SCHEMBL4667597 0.84 CYP2D6 (0.76) SLC6A2SLC6A4SLC6A3CYP2D6CHRM2
SCHEMBL15529408 0.84 SLC6A2 (0.76) SLC6A2SLC6A4SLC6A3CYP2D6CHRM2
SCHEMBL7688529 0.82 CYP2D6 (0.74) SLC6A2SLC6A4SLC6A3CYP2D6CHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 183 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8268352-B2 Modified release composition for highly soluble drugs TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-18 US claimed
US-8263125-B2 Dosage form for high dose-high solubility active ingredients that provides for immediate release and modified release of the active ingredients TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-11 US claimed
US-20060024365-A1 Novel dosage form VAYA NAVIN 2006-02-02 US claimed
US-20060018933-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
US-20060018934-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
EP-4706683-A2 CHEWABLE FORMULATIONS Elanco Tiergesundheit AG (CH) 2026-03-11 EP disclosed
US-20260034059-A1 ORAL FILM COMPOSITIONS AND DOSAGE FORMS HAVING PRECISE ACTIVE DISSOLUTION PROFILES AQUESTIVE THERAPEUTICS, INC. (US) 2026-02-05 US disclosed
US-12465564-B2 Oral and nasal compositions and methods of treatment AQUESTIVE THERAPEUTICS, INC. (US) 2025-11-11 US disclosed
US-20250339367-A1 ORAL FILM COMPOSITIONS AND DOSAGE FORMS HAVING PRECISE ACTIVE DISSOLUTION PROFILES AQUESTIVE THERAPEUTICS, INC. (US) 2025-11-06 US disclosed
US-12403090-B2 Oral film compositions and dosage forms having precise active dissolution profiles AQUESTIVE THERAPEUTICS, INC. (US) 2025-09-02 US disclosed
US-20250255780-A1 SYSTEM AND METHOD FOR MAKING PERSONALIZED INDIVIDUAL UNIT DOSES CONTAINING PHARMACEUTICAL ACTIVES AQUESTIVE THERAPEUTICS, INC. (US) 2025-08-14 US disclosed
US-12310922-B2 System and method for making personalized individual unit doses containing pharmaceutical actives AQUESTIVE THERAPEUTICS, INC. (US) 2025-05-27 US disclosed
US-20010002404-A1 Fatty acid-pharmaceutical agent conjugates LUITPOLD PHARMACEUTICALS, INC. 2001-05-31 US disclosed
WO-2001007009-A1 LYSINE OXIDASE LINKAGE OF AGENTS TO TISSUE PERICOR SCIENCE, INC. (US) 2001-02-01 WO disclosed
WO-2001006829-A2 LINKAGE OF AGENTS TO TISSUE PERICOR SCIENCE, INC. (US) 2001-02-01 WO disclosed
EP-1054998-A1 TRANSGLUTAMINASE LINKAGE OF AGENTS TO TISSUE Pericor Science, Inc. (US) 2000-11-29 EP disclosed
WO-2000053231-A2 FATTY ACID-ANTICANCER CONJUGATES AND USES THEREOF PROTARGA, INC. (US) 2000-09-14 WO disclosed
WO-1999036570-A2 TRANSGLUTAMINASE LINKAGE OF AGENTS TO TISSUE PERICOR SCIENCE INC (US) 1999-07-22 WO disclosed
WO-1999030690-A1 ORAL DELIVERY FORMULATION AXIA THERAPEUTICS, INC. (US) 1999-06-24 WO disclosed
US-5795909-A ANTICARCINOGENIC AND ANTITUMOR AGENTS; BREAST, COLON, OVARIANCANCERS NEUROMEDICA, INC. (US) 1998-08-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010002404-A1 Fatty acid-pharmaceutical agent conjugates FABP7, FFAR2, FFAR4 SLC6A2 644/4885SLC6A4 642/4885SLC6A3 916/4885
US-20260034059-A1 ORAL FILM COMPOSITIONS AND DOSAGE FORMS HAVING PRECISE ACTIVE DISSOLUTION PROFILES SORD, SLC6A13, CACNA1A SLC6A2 286/4885SLC6A4 120/4885SLC6A3 291/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.