SCHEMBL6375258

SCHEMBL6375258

N[C@@H](CO)CCCNC(=O)OCc1ccccc1

nearest known ligand 0.62

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.62
SLC1A3 P43003 1/20 0.58
SLC1A1 P43005 1/20 0.58
LMNA P02545 1/20 0.57
SMN1; SMN2 Q16637 1/20 0.57
DPP8 Q6V1X1 2/20 0.57
DPP7 Q9UHL4 2/20 0.57
TGM2 P21980 1/20 0.55
ANPEP P15144 1/20 0.55
KEAP1 Q14145 2/20 0.54
NFE2L2 Q16236 2/20 0.54
FOLH1 Q04609 3/20 0.53
DPP4 P27487 1/20 0.53
DPP9 Q86TI2 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6374328 0.99 HTT (0.60) HTTSLC1A3SLC1A1LMNASMN1; SMN2
SCHEMBL3181613 0.96 DPP8 (0.61) HTTSLC1A3SLC1A1LMNASMN1; SMN2
SCHEMBL2033858 0.96 DPP8 (0.61) HTTSLC1A3SLC1A1LMNASMN1; SMN2
SCHEMBL2032072 0.96 DPP8 (0.61) HTTSLC1A3SLC1A1LMNASMN1; SMN2
SCHEMBL2228405 0.95 DPP8 (0.60) HTTSLC1A3SLC1A1LMNASMN1; SMN2
SCHEMBL1586589 0.89 HTT (0.62) HTTSLC1A3SLC1A1LMNASMN1; SMN2
SCHEMBL1586590 0.89 HTT (0.62) HTTSLC1A3SLC1A1LMNASMN1; SMN2
SCHEMBL31295310 0.88 HTT (0.64) HTTSLC1A3SLC1A1LMNASMN1; SMN2
SCHEMBL13995289 0.86 HTT (0.58) HTTSLC1A3SLC1A1LMNASMN1; SMN2
SCHEMBL1586919 0.85 DPP8 (0.61) HTTSLC1A3SLC1A1LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130022628-A1 ACYL PSEUDOPEPTIDES WHICH CARRY A FUNCTIONALIZED AUXILIARY ARM OM PHARMA (CH) 2013-01-24 US claimed
EP-3842437-A1 HIGH ACTIVITY STING PROTEIN AGONIST Adlai Nortye Biopharma Co., Ltd. (CN) 2021-06-30 EP disclosed
US-20130022628-A1 ACYL PSEUDOPEPTIDES WHICH CARRY A FUNCTIONALIZED AUXILIARY ARM OM PHARMA (CH) 2013-01-24 US disclosed
US-20050192232-A1 Novel acyl-dipeptide-like compounds bearing an accessory functional side chain spacer, a method for preparing the same and pharmaceutical compositions containing such products OM PHARMA (CH) 2005-09-01 US disclosed
CN-1434795-A Acylated Pseudodipeptides with Functionalized Auxiliary Branches OM PHARMA (CH) 2003-08-06 CN disclosed
EP-1242365-A1 ACYL PSEUDODIPEPTIDES WHICH CARRY A FUNCTIONALISED AUXILIARY ARM OM Pharma (CH) 2002-09-25 EP disclosed
WO-2001046126-A1 ACYL PSEUDODIPEPTIDES WHICH CARRY A FUNCTIONALISED AUXILIARY ARM OM PHARMA (CH) 2001-06-28 WO disclosed
WO-2001046127-A1 ACYL PSEUDOPEPTIDES BEARING A FUNCTIONALISED AUXILIARY SPACER OM PHARMA (CH) 2001-06-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050192232-A1 Novel acyl-dipeptide-like compounds bearing an accessory functional side chain spacer, a method for preparing the same and pharmaceutical compositions containing such products PIGS, AADAT, CD74 HTT 3254/4885SLC1A3 637/4885SLC1A1 510/4885
US-20130022628-A1 ACYL PSEUDOPEPTIDES WHICH CARRY A FUNCTIONALIZED AUXILIARY ARM PIGS, ENPEP, DNPEP HTT 2783/4885SLC1A3 1273/4885SLC1A1 1143/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.