Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLP1R | P43220 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 8/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6376375 | 0.88 | GLP1R (0.34) | GLP1RNOTUMGABRA2NPC1ALDH1A1 | |
| SCHEMBL6375996 | 0.85 | GLP1R (0.43) | GLP1RNOTUMGABRA2GABRB2NPC1 | |
| SCHEMBL6595978 | 0.85 | NOTUM (0.39) | GLP1RNOTUMGABRA2GABRB2ALDH1A1 | |
| SCHEMBL6380913 | 0.85 | GRIA1 (0.41) | ALDH1A1 | |
| SCHEMBL6377440 | 0.82 | GRIA1 (0.42) | — | |
| SCHEMBL6600183 | 0.73 | L3MBTL1 (0.43) | NOTUMNPC1ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL6606958 | 0.72 | ALDH1A1 (0.36) | NPC1ALDH1A1MAPTXBP1NPSR1 | |
| SCHEMBL6381602 | 0.71 | GLP1R (0.49) | GLP1RNPC1ALDH1A1TP53MAPT | |
| SCHEMBL6595746 | 0.71 | NOTUM (0.38) | GLP1RNOTUMGABRA2GABRB2ALDH1A1 | |
| SCHEMBL6595960 | 0.71 | ALDH1A1 (0.38) | ALDH1A1XBP1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1156047-B1 | 6-SUBSTITUTED-7- HETEROQUINOXALINE CARBOXYLIC ACID DERIVATIVES AND ADDITION SALTS THEREOF AND PROCESSES FOR THE PREPARATION OF BOTH | KYORIN SEIYAKU KK (JP) | 2005-08-31 | — | — | EP | disclosed |
| US-6632813-B1 | 6-subtituted-7-heteroquinoxalinecarboxylic acid derivatives and addition salts thereof and processes for the preparation of both | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2003-10-14 | — | — | US | disclosed |
| EP-1156047-A1 | 6-SUBSTITUTED-7- HETEROQUINOXALINE CARBOXYLIC ACID DERIVATIVES AND ADDITION SALTS THEREOF AND PROCESSES FOR THE PREPARATION OF BOTH | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2001-11-21 | — | — | EP | disclosed |