Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.45 |
| ▸ | GPR3 | P46089 | 2/20 | 0.45 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | NCF1 | P14598 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL444551 | 0.73 | GPR3 (0.39) | ALDH1A1CYP1A2HSD17B10HPGDGPR3 | |
| SCHEMBL623055 | 0.73 | DCPS (0.48) | ALDH1A1CYP1A2HSD17B10HPGDNUDT1 | |
| SCHEMBL558169 | 0.73 | CYP1A2 (0.39) | ALDH1A1CYP1A2HSD17B10HPGDGPR3 | |
| SCHEMBL7039137 | 0.73 | GPR3 (0.39) | ALDH1A1CYP1A2HSD17B10HPGDGPR3 | |
| SCHEMBL7972478 | 0.73 | PDE4A (0.48) | ALDH1A1CYP1A2HSD17B10HPGDGPR3 | |
| SCHEMBL7976154 | 0.72 | ALDH1A1 (0.48) | ALDH1A1CYP1A2HPGDMPOKDM4E | |
| SCHEMBL638754 | 0.72 | GPR3 (0.34) | ALDH1A1CYP1A2GPR3MPOPOLB | |
| SCHEMBL2303106 | 0.72 | ATM (0.36) | ALDH1A1CYP1A2HSD17B10HPGDGPR3 | |
| SCHEMBL637564 | 0.72 | SMN1; SMN2 (0.47) | ALDH1A1CYP1A2HSD17B10HPGDNUDT1 | |
| SCHEMBL23295733 | 0.71 | ELANE (0.39) | CYP1A2CYP2A6ELANEPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 127 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3424926-A1 | 8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINS, THEIR PRODUCTION AND UTILISATION AS MEDICINE | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2019-01-09 | — | — | EP | claimed |
| EP-1720835-B1 | NOVEL GUANIDINYL-SUBSTITUTED HYDROXY-6-PHENYLPHENANTHRIDINES AS EFFECTIVE PHOSPHODIESTERASE (PDE) 4 INHIBITORS | NYCOMED GMBH (DE) | 2012-12-12 | — | — | EP | claimed |
| JP-4728259-B2 | — | — | 2011-07-20 | — | — | JP | claimed |
| EP-2308878-A2 | 8-[3-amino-piperidin-1-yl]-xanthines, the production thereof and use as medicaments | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2011-04-13 | — | — | EP | claimed |
| EP-1709049-B1 | BICYCLIC IMIDAZOLE COMPOUNDS, THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM INT (DE) | 2010-08-18 | — | — | EP | claimed |
| US-7550455-B2 | 8-(piperazin-1yl)- and 8-([1,4]diazepan-1yl)-xanthines, the preparation thereof and their use as pharmaceutical composition | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-06-23 | — | — | US | claimed |
| EP-2070539-A1 | 8-[3-amino-piperidin-1-yl]-xanthins, their production and utilisation as medicine | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2009-06-17 | — | — | EP | claimed |
| EP-2060573-A2 | 8-[3-amino-piperidin-1-yl]-xanthins, their production and utilisation as medicine | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2009-05-20 | — | — | EP | claimed |
| EP-2058311-A2 | 8-[3-amino-piperidin-1-yl]-xanthins, their production and utilisation as medicine | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2009-05-13 | — | — | EP | claimed |
| JP-4233524-B2 | — | — | 2009-03-04 | — | — | JP | claimed |
| WO-2005051950-A1 | NOVEL 8-(PIPERAZINE-1-YL)- AND 8-([1,4]DIAZEPAN-1-YL)-XANTHINE, THE PRODUCTION AND USE THEREOF IN THE FROM OF A DRUG | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-06-09 | — | — | WO | claimed |
| EP-1537086-A2 | NOVEL PHENANTHRIDINES | ALTANA Pharma AG (DE) | 2005-06-08 | — | — | EP | claimed |
| EP-1532149-A2 | 8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINES, THE PRODUCTION THEREOF AND THE USE OF THE SAME AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-05-25 | — | — | EP | claimed |
| US-20040097510-A1 | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-05-20 | — | — | US | claimed |
| WO-2004018431-A2 | NOVEL PHENANTHRIDINES | ALTANA PHARMA AG (DE) | 2004-03-04 | — | — | WO | claimed |
| WO-2004018468-A2 | 8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINES, THE PRODUCTION THEREOF AND THE USE OF THE SAME AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-03-04 | — | — | WO | claimed |
| WO-2004018465-A2 | BENZONAPHTHYRIDINES WITH PDE 3/4 INHIBITING ACTIVITY | ALTANA PHARMA AG (DE) | 2004-03-04 | — | — | WO | claimed |
| EP-0337308-B1 | 2-Pyridylmethylthio derivatives and antiulcer agents | NISSHIN FLOUR MILLING CO (JP) | 1994-11-30 | — | — | EP | claimed |
| US-4925843-A | SUBSTITUTED ON QUINAZOLINE, PHTHALAZINE OR PYRIDO(2,3-D)PYRIMIDINE MOIETIES | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1990-05-15 | — | — | US | claimed |
| EP-0337308-A2 | 2-Pyridylmethylthio derivatives and antiulcer agents | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1989-10-18 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040097510-A1 | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions | DPP8, DPP4, DPP3 | ALDH1A1 295/4885CYP1A2 313/4885HSD17B10 2750/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.