Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | F12 | P00748 | 1/20 | 0.31 |
| ▸ | CDK7 | P50613 | 1/20 | 0.30 |
| ▸ | CCNH | P51946 | 1/20 | 0.30 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.30 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3457767 | 0.84 | F12 (0.33) | C5AR1NR1H2ADORA1F12 | |
| SCHEMBL596325 | 0.82 | ADORA1 (0.38) | C5AR1NR1H2ADORA1F12 | |
| SCHEMBL19200586 | 0.80 | C5AR1 (0.41) | C5AR1NR1H2ADORA1 | |
| SCHEMBL6377226 | 0.78 | C5AR1 (0.36) | C5AR1 | |
| SCHEMBL3327257 | 0.77 | C5AR1 (0.33) | C5AR1 | |
| SCHEMBL19201023 | 0.77 | C5AR1 (0.32) | C5AR1F12 | |
| SCHEMBL1368936 | 0.74 | CDK2 (0.42) | C5AR1NR1H2CDK7CCNHCCNA2 | |
| SCHEMBL18155648 | 0.73 | C5AR1 (0.32) | C5AR1 | |
| SCHEMBL16622327 | 0.73 | C5AR1 (0.37) | C5AR1NR1H2ADORA1 | |
| SCHEMBL25340650 | 0.71 | F12 (0.40) | NR1H2ADORA1F12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8999981-B2 | 3-amido-pyrrolo[3,4-C]pyrazole-5(1H, 4H,6H) carbaldehyde derivatives | PFIZER INC. (US) | 2015-04-07 | — | — | US | disclosed |
| US-20120108588-A1 | NOVEL 3-AMIDO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H,6H) CARBALDEHYDE DERIVATIVES | PFIZER, INC. (US) | 2012-05-03 | — | — | US | disclosed |
| US-8114871-B2 | 3-amido-pyrrolo[3,4-C]pyrazole-5(1H,4H,6H) carbaldehyde derivatives | PFIZER INC. (US) | 2012-02-14 | — | — | US | disclosed |
| US-20100249128-A1 | NOVEL 3-AMIDO-PYRROLO[3,4-C]PYRAZOLE-5(1H,4H,6H) CARBALDEHYDE DERIVATIVES | PFIZER INC. | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249128-A1 | NOVEL 3-AMIDO-PYRROLO[3,4-C]PYRAZOLE-5(1H,4H,6H) CARBALDEHYDE DERIVATIVES | INSR, IAPP, PYCR1 | C5AR1 438/4885NR1H2 389/4885ADORA1 221/4885 |
| US-20120108588-A1 | NOVEL 3-AMIDO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H,6H) CARBALDEHYDE DERIVATIVES | INSR, IAPP, PYCR1 | C5AR1 438/4885NR1H2 389/4885ADORA1 221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.