Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.32 |
| ▸ | F12 | P00748 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL596325 | 0.87 | ADORA1 (0.38) | C5AR1F12 | |
| SCHEMBL3457767 | 0.85 | F12 (0.33) | C5AR1F12JAK1 | |
| SCHEMBL19200992 | 0.80 | BUB1 (0.32) | C5AR1 | |
| SCHEMBL16622327 | 0.78 | C5AR1 (0.37) | C5AR1 | |
| SCHEMBL6375680 | 0.77 | C5AR1 (0.35) | C5AR1F12 | |
| SCHEMBL28926418 | 0.74 | — | — | |
| SCHEMBL6377226 | 0.73 | C5AR1 (0.36) | C5AR1 | |
| SCHEMBL19312086 | 0.72 | C5AR1 (0.35) | C5AR1JAK2JAK1 | |
| SCHEMBL3327257 | 0.71 | C5AR1 (0.33) | C5AR1 | |
| SCHEMBL24272891 | 0.71 | C5AR1 (0.32) | C5AR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10316045-B2 | Substituted pyrrolo[3,4-c]pyrazoles as pkc kinase inhibitors | PFIZER INC. (US) | 2019-06-11 | — | — | US | disclosed |
| US-20170217991-A1 | NOVEL 3-AMINO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H,6H) CARBALDEHYDE DERIVATIVES | PFIZER INC. | 2017-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170217991-A1 | NOVEL 3-AMINO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H,6H) CARBALDEHYDE DERIVATIVES | INSR, IAPP, GPR119 | C5AR1 1187/4885F12 1339/4885JAK2 29/4885 |
| US-10316045-B2 | Substituted pyrrolo[3,4-c]pyrazoles as pkc kinase inhibitors | PRKCB, PRKCA, PRKCE | C5AR1 3054/4885F12 941/4885JAK2 91/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.