Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.36 |
| ▸ | NPY2R | P49146 | 6/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6375766 | 0.79 | KMT2A (0.45) | KMT2AMEN1ALDH1A1LMNAOPRL1 | |
| SCHEMBL5349092 | 0.76 | GABRA1 (0.54) | KMT2AMEN1ALDH1A1LMNAOPRK1 | |
| SCHEMBL27528615 | 0.73 | KMT2A (0.42) | KMT2AMEN1ALDH1A1LMNAOPRL1 | |
| SCHEMBL11275312 | 0.69 | KMT2A (0.50) | KMT2AMEN1ALDH1A1LMNAOPRL1 | |
| SCHEMBL23886508 | 0.67 | CYP3A4 (0.60) | KMT2AMEN1ALDH1A1LMNAOPRL1 | |
| SCHEMBL6785068 | 0.67 | GABRA1 (0.46) | ALDH1A1LMNAOPRL1OPRK1MAPT | |
| SCHEMBL10862008 | 0.67 | KMT2A (0.71) | KMT2AMEN1ALDH1A1LMNAOPRL1 | |
| SCHEMBL3195392 | 0.65 | KMT2A (0.68) | KMT2AMEN1ALDH1A1LMNAOPRL1 | |
| SCHEMBL7657250 | 0.65 | LMNA (0.94) | KMT2AMEN1ALDH1A1LMNAOPRL1 | |
| SCHEMBL3195397 | 0.65 | KMT2A (0.68) | KMT2AMEN1ALDH1A1LMNAOPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272666-A1 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds | WU JING | 2005-12-08 | — | — | US | disclosed |
| US-6632811-B2 | Administering cycloalkyl, lactam, lactone compounds for for inhibiting beta -amyloid peptide release and/or its synthesis in a cell | ATHENA NEUROSCIENCES, INC. | 2003-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272666-A1 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds | BACE1, APP, BACE2 | KMT2A 4749/4885MEN1 1035/4885ALDH1A1 3897/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.