Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 9/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.34 |
| ▸ | USP2 | O75604 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 2/20 | 0.33 |
| ▸ | CASP7 | P55210 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL543514 | 0.75 | ALDH1A1 (0.38) | ALDH1A1HSD17B10MEN1KMT2AMAPT | |
| SCHEMBL544146 | 0.72 | HSD17B10 (0.33) | ALDH1A1HSD17B10MEN1KMT2AMAPT | |
| SCHEMBL543720 | 0.66 | ALDH1A1 (0.44) | ALDH1A1HSD17B10MEN1KMT2AMAPT | |
| SCHEMBL543818 | 0.65 | HSD17B10 (0.32) | ALDH1A1HSD17B10MEN1KMT2AMAPT | |
| SCHEMBL5736298 | 0.58 | POLB (0.39) | ALDH1A1MEN1KMT2ATSHRHPGD | |
| SCHEMBL7820085 | 0.57 | ALDH1A1 (0.61) | ALDH1A1HSD17B10MEN1KMT2AMAPT | |
| SCHEMBL30960368 | 0.56 | GRIN2B (0.44) | ALDH1A1HSD17B10MEN1KMT2AMAPT | |
| SCHEMBL17033075 | 0.56 | HSD11B1 (0.43) | ALDH1A1HSD17B10MEN1KMT2AMAPT | |
| SCHEMBL6944202 | 0.55 | HTT (0.64) | ALDH1A1HSD17B10MEN1KMT2AMAPT | |
| SCHEMBL8114202 | 0.55 | HTT (0.64) | ALDH1A1HSD17B10MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2388000-B1 | Neuroprotectant containing heterocyclic compound having specific structure | ZENYAKU KOGYO KK (JP) | 2016-04-06 | — | — | EP | disclosed |
| EP-2077836-B1 | AMYLOID BETA DEPOSITION INHIBITOR CONTAINING SPIRO-HETEROCYCLIC COMPOUND | ZENYAKU KOGYO KK (JP) | 2016-03-09 | — | — | EP | disclosed |
| EP-2388001-B1 | Age retardant containing heterocyclic compound having specific structure | ZENYAKU KOGYO KK (JP) | 2015-12-16 | — | — | EP | disclosed |
| US-9089561-B2 | Methods for treating depression, neurodegeneration, inhibiting amyloid β deposition, delaying senescence, and extending life spans with heterocyclic compounds | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 2015-07-28 | — | — | US | disclosed |
| US-20140171452-A1 | METHODS FOR TREATING DEPRESSION, NEURODEGENERATION, INHIBITING AMYLOID BETA DEPOSITION, DELAYING SENESCENCE, AND EXTENDING LIFE SPANS WITH HETEROCYCLIC COMPOUNDS | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 2014-06-19 | — | — | US | disclosed |
| EP-2388002-B1 | Antidepressant containing heterocyclic compound having specific structure | ZENYAKU KOGYO KK (JP) | 2013-03-13 | — | — | EP | disclosed |
| WO-2012094612-A1 | METHOD OF TREATING ESSENTIAL TREMOR | ZENYAKU KOGYO KABUSHIKIKAISHA (JP) | 2012-07-12 | — | — | WO | disclosed |
| WO-2012094615-A2 | USE OF CAV3.1 SELECTIVE T-TYPE CALCIUM CHANNEL ANTAGONISTS | ZENYAKU KOGYO KABUSHIKIKAISHA (JP) | 2012-07-12 | — | — | WO | disclosed |
| EP-2429522-A2 | METHOD OF DECREASING UBIQUITYLATED PROTEIN LEVELS | The Regents of the University of California Office of Technology Transfer (US) | 2012-03-21 | — | — | EP | disclosed |
| EP-2419100-A2 | METHOD OF DECREASING PRO-ADAM10 SECRETASE AND/OR BETA SECRETASE LEVELS | Green, Kim Nicholas (US) | 2012-02-22 | — | — | EP | disclosed |
| US-20100267763-A1 | Method of Decreasing Pro-ADAM10 Secretase and/or Beta Secretase Levels | ZENYAKU KOGYO KABUSHIKIKAISHA (JP) | 2010-10-21 | — | — | US | disclosed |
| WO-2010120872-A2 | METHOD OF DECREASING PRO-ADAM10 SECRETASE AND/OR BETA SECRETASE LEVELS | GREEN KIM NICHOLAS (US) | 2010-10-21 | — | — | WO | disclosed |
| US-20100256173-A1 | Method of Treating Cognitive Impairment | ZENYAKU KOGYO CO., LTD. (JP) | 2010-10-07 | — | — | US | disclosed |
| WO-2010077852-A2 | METHOD OF INDUCING CLEAVAGE OF AMYLOID PRECURSOR PROTEIN TO FORM A NOVEL FRAGMENT | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-07-08 | — | — | WO | disclosed |
| US-20100168135-A1 | Method of Inducing Cleavage of Amyloid Precursor Protein to Form a Novel Fragment | ZENYAKU KOGYO KABUSHIKIKAISHA (JP) | 2010-07-01 | — | — | US | disclosed |
| EP-2077835-A2 | AN ALZHEIMER'S DISEASE PROGRESSION INHIBITOR CONTAINING HETEROCYCLIC COMPOUND | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 2009-07-15 | — | — | EP | disclosed |
| US-20080103158-A1 | spiro[imidazo[1,2-a]pyridin-2(3H)-one-3,2'-indan]; antidepressant, neuroprotectant, antiaging agent; manic depressive psychoses, obsessive-compulsive disorder; orally | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 2008-05-01 | — | — | US | disclosed |
| US-20080103157-A1 | 3,3-dibenzylimidazo[1,2-a]pyridin-2(3H)-one; antidepressant, neuroprotectant, antiaging agent; manic depressive psychoses, obsessive-compulsive disorder; orally | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 2008-05-01 | — | — | US | disclosed |
| WO-2008047951-A2 | AN ALZHEIMER' S DISEASE PROGRESSION INHIBITOR CONTAINING HETEROCYCLIC COMPOUND | ZENYAKU KOGYO KABUSHIKIKAISHA (JP) | 2008-04-24 | — | — | WO | disclosed |
| US-20040048879-A1 | Heterocyclic compounds and cerebral function improvers containing the same as the active ingredient | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 2004-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080103158-A1 | spiro[imidazo[1,2-a]pyridin-2(3H)-one-3,2'-indan]; antidepressant, neuroprotectant, antiaging agent; manic depressive psychoses, obsessive-compulsive disorder; orally | PSEN1, PSEN2, GRN | ALDH1A1 116/4885HSD17B10 1019/4885MEN1 2350/4885 |
| US-20100168135-A1 | Method of Inducing Cleavage of Amyloid Precursor Protein to Form a Novel Fragment | APP, APBA1, BACE1 | ALDH1A1 3405/4885HSD17B10 1319/4885MEN1 1368/4885 |
| US-20080103157-A1 | 3,3-dibenzylimidazo[1,2-a]pyridin-2(3H)-one; antidepressant, neuroprotectant, antiaging agent; manic depressive psychoses, obsessive-compulsive disorder; orally | PSEN1, PSEN2, BDNF | ALDH1A1 159/4885HSD17B10 761/4885MEN1 2755/4885 |
| US-20040048879-A1 | Heterocyclic compounds and cerebral function improvers containing the same as the active ingredient | CBR1, CBR3, CHAT | ALDH1A1 1111/4885HSD17B10 805/4885MEN1 3473/4885 |
| US-20100256173-A1 | Method of Treating Cognitive Impairment | HTT, CHAT, PSEN2 | ALDH1A1 3700/4885HSD17B10 647/4885MEN1 3580/4885 |
| US-20100267763-A1 | Method of Decreasing Pro-ADAM10 Secretase and/or Beta Secretase Levels | BACE1, BACE2, APP | ALDH1A1 2050/4885HSD17B10 288/4885MEN1 433/4885 |
| US-20140171452-A1 | METHODS FOR TREATING DEPRESSION, NEURODEGENERATION, INHIBITING AMYLOID BETA DEPOSITION, DELAYING SENESCENCE, AND EXTENDING LIFE SPANS WITH HETEROCYCLIC COMPOUNDS | PSEN1, GAP43, PSEN2 | ALDH1A1 905/4885HSD17B10 504/4885MEN1 3865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.