Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6377374 | 0.77 | CYP19A1 (0.41) | ALDH1A1KMT2AMEN1CYP19A1MAPT | |
| SCHEMBL3800700 | 0.75 | SCD (0.54) | ALDH1A1KMT2AMEN1CYP19A1MAPT | |
| SCHEMBL8586662 | 0.75 | CYP19A1 (0.40) | ALDH1A1KMT2AMEN1CYP19A1MAPT | |
| SCHEMBL2154883 | 0.74 | ALDH1A1 (0.40) | ALDH1A1KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL2154456 | 0.74 | ALDH1A1 (0.40) | ALDH1A1KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL623489 | 0.73 | NPSR1 (0.37) | KMT2AMEN1SMN1; SMN2LMNAHTT | |
| SCHEMBL1473123 | 0.73 | SCD (0.55) | ALDH1A1KMT2AMEN1CYP19A1MAPT | |
| SCHEMBL1554958 | 0.73 | TDP1 (0.52) | ALDH1A1KMT2AMEN1CYP19A1MAPT | |
| SCHEMBL3549018 | 0.72 | MAOB (0.40) | ALDH1A1ALOX15 | |
| SCHEMBL8477687 | 0.71 | PDE5A (0.53) | PDE5APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050119262-A1 | Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent | PHARMACIA CORPORATION (US) | 2005-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119262-A1 | Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent | PTGS2, PTGS1, PTGES2 | ALDH1A1 1551/4885KMT2A 3426/4885MEN1 2776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.