Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6079897 | 0.85 | ALDH1A1 (0.49) | TDP1ALDH1A1L3MBTL1HSD17B10KMT2A | |
| SCHEMBL11336213 | 0.81 | ALDH1A1 (0.47) | TDP1ALDH1A1L3MBTL1HSD17B10KMT2A | |
| SCHEMBL27802343 | 0.80 | NPC1 (0.46) | TDP1ALDH1A1L3MBTL1HSD17B10KMT2A | |
| SCHEMBL16959165 | 0.77 | TDP1 (0.37) | TDP1ALDH1A1HSD17B10TSHRKMT2A | |
| SCHEMBL11145042 | 0.77 | PIN1 (0.46) | TDP1ALDH1A1L3MBTL1HSD17B10KMT2A | |
| SCHEMBL5655061 | 0.77 | KMT2A (0.38) | TDP1ALDH1A1L3MBTL1HSD17B10TSHR | |
| SCHEMBL11355163 | 0.77 | NPC1 (0.42) | TDP1ALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL28371226 | 0.76 | ALDH1A1 (0.42) | TDP1ALDH1A1L3MBTL1HSD17B10TSHR | |
| SCHEMBL8374 | 0.75 | TDP1 (0.54) | TDP1ALDH1A1L3MBTL1HSD17B10TSHR | |
| SCHEMBL7907932 | 0.75 | TDP1 (0.45) | TDP1ALDH1A1L3MBTL1HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8916711-B2 | Imidazothiazole-chalcone derivatives as potential anticancer agents and process for the preparation thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2014-12-23 | — | — | US | claimed |
| EP-2488533-B1 | IMIDAZOTHIAZOLE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2014-07-23 | — | — | EP | claimed |
| US-20120271054-A1 | IMIDAZOTHIAZOLE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2012-10-25 | — | — | US | claimed |
| EP-2488533-A1 | IMIDAZOTHIAZOLE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | Council of Scientific & Industrial Research (IN) | 2012-08-22 | — | — | EP | claimed |
| WO-2011045646-A1 | IMIDAZOTHIAZOLE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2011-04-21 | — | — | WO | claimed |
| EP-1363925-B8 | MACROLIDE ANTIBIOTICS | GLAXO GROUP LTD (GB) | 2007-04-25 | — | — | EP | claimed |
| EP-1363925-A1 | MACROLIDE ANTIBIOTICS | GLAXO GROUP LIMITED (GB) | 2003-11-26 | — | — | EP | claimed |
| WO-2002050091-A1 | MACROLIDE ANTIBIOTICS | GLAXO GROUP LIMITED (GB) | 2002-06-27 | — | — | WO | claimed |
| US-6211240-B1 | INSECTICIDES | NOVARTIS CORPORATION | 2001-04-03 | — | — | US | claimed |
| EP-0651737-B1 | O-BENZYL OXIME ETHER DERIVATIVES AND THEIR USE AS PESTICIDES | CIBA GEIGY AG (CH) | 1998-07-29 | — | — | EP | claimed |
| EP-0835242-A1 | THIOAMIDES S-OXIDES FOR USE AS PESTICIDES | Novartis AG (CH) | 1998-04-15 | — | — | EP | claimed |
| WO-1997000859-A1 | THIOAMIDES S-OXIDES FOR USE AS PESTICIDES | NOVARTIS AG (CH) | 1997-01-09 | — | — | WO | claimed |
| WO-1996006072-A1 | OXIME ETHERS AND THEIR USE AS PESTICIDES | CIBA-GEIGY AG (CH) | 1996-02-29 | — | — | WO | claimed |
| EP-0651737-A1 | O-BENZYL OXIME ETHER DERIVATIVES AND THEIR USE AS PESTICIDES | Novartis AG (CH) | 1995-05-10 | — | — | EP | claimed |
| WO-1994026700-A1 | O-BENZYL OXIME ETHER DERIVATIVES AND THEIR USE AS PESTICIDES | CIBA-GEIGY AG (CH) | 1994-11-24 | — | — | WO | claimed |
| EP-0034743-B1 | BENZOXAZOLES, THEIR PREPARATION AND THEIR USE AS MEDICINES | Dr. Karl Thomae GmbH (DE) | 1984-05-30 | — | — | EP | claimed |
| US-4010162-A | Substituted phenanthroline pigments | ALLIED CHEMICAL CORPORATION (US) | 1977-03-01 | — | — | US | claimed |
| WO-2024120471-A1 | COMPOUNDS TARGETING MUTANT OF P53 | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2024-06-13 | — | — | WO | disclosed |
| EP-0009298-A1 | Heterocyclic compounds, processes for their preparation, pesticidal compositions containing them and methods of combating pests | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1980-04-02 | — | — | EP | disclosed |
| EP-0007707-A1 | 1,3-Diazol- and 1,2,4-triazol-derivatives, processes for their preparation, pesticidal compositions containing them and methods of combating pests | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1980-02-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120271054-A1 | IMIDAZOTHIAZOLE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | EIF4A1, CYP2C18, UGT2B17 | TDP1 4118/4885ALDH1A1 450/4885L3MBTL1 4197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.