Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 3/20 | 0.60 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.45 |
| ▸ | HPD | P32754 | 3/20 | 0.43 |
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6382809 | 0.83 | MMP13 (0.53) | MMP13PTPN1MMP1ADAM17MAOB | |
| SCHEMBL6382057 | 0.80 | MMP13 (0.75) | MMP13PTPN1MAOBNR4A2MMP2 | |
| SCHEMBL6381248 | 0.80 | MMP13 (0.48) | MMP13MMP1ADAM17MAOBMMP2 | |
| SCHEMBL6380934 | 0.77 | MMP13 (0.45) | MMP13ADAM17MAOBMMP2MMP14 | |
| SCHEMBL6375122 | 0.75 | MMP13 (0.43) | MMP13ADAM17MAOBMMP2MMP14 | |
| SCHEMBL6383331 | 0.75 | MMP13 (0.54) | MMP13PTPN1MAOBNR4A2MMP2 | |
| SCHEMBL6377115 | 0.73 | MMP13 (0.90) | MMP13ADAM17MMP2MMP14 | |
| SCHEMBL6378906 | 0.73 | MMP13 (0.90) | MMP13MAOBMMP2MMP14 | |
| SCHEMBL6377111 | 0.71 | MMP13 (0.70) | MMP13PTPN1ADAM17MAOBNR4A2 | |
| SCHEMBL94569 | 0.69 | NSD2 (0.51) | HPDNR4A2MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202974-B1 | PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | PFIZER PROD INC (US) | 2005-11-09 | — | — | EP | disclosed |
| US-6579982-B1 | Treating inflammation, cancer | PFIZER INC. | 2003-06-17 | — | — | US | disclosed |
| EP-1202974-A1 | PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | Pfizer Products Inc. (US) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001012611-A1 | PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2001-02-22 | — | — | WO | disclosed |