Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 8/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.45 |
| ▸ | MMP2 | P08253 | 3/20 | 0.44 |
| ▸ | MMP14 | P50281 | 3/20 | 0.44 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.44 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 3/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6381248 | 0.87 | MMP13 (0.48) | MMP13MMP2MMP14MMP1ADAM17 | |
| SCHEMBL6380934 | 0.84 | MMP13 (0.45) | MMP13MMP2MMP14ADAM17MAOB | |
| SCHEMBL6377995 | 0.83 | MMP13 (0.60) | MMP13PTPN1MMP2MMP14MEN1 | |
| SCHEMBL6375122 | 0.82 | MMP13 (0.43) | MMP13MMP2MMP14ADAM17MAOB | |
| SCHEMBL6383331 | 0.80 | MMP13 (0.54) | MMP13PTPN1MMP2MMP14MAOB | |
| SCHEMBL6382057 | 0.75 | MMP13 (0.75) | MMP13RAB9APTPN1MMP2MMP14 | |
| SCHEMBL6377947 | 0.73 | MMP13 (0.63) | MMP13MMP2MMP14MMP3MMP9 | |
| SCHEMBL222118 | 0.73 | MMP13 (0.63) | MMP13MMP2MMP14MMP3MMP9 | |
| SCHEMBL6236731 | 0.73 | MAOB (0.57) | MMP13RAB9AMMP2MMP14ADAMTS4 | |
| SCHEMBL5921916 | 0.72 | RAB9A (0.56) | MMP13RAB9AMMP2MMP14ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202974-B1 | PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | PFIZER PROD INC (US) | 2005-11-09 | — | — | EP | disclosed |
| US-6579982-B1 | Treating inflammation, cancer | PFIZER INC. | 2003-06-17 | — | — | US | disclosed |