Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 2/20 | 0.75 |
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 9/20 | 0.50 |
| ▸ | MAOA | P21397 | 3/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6383331 | 0.86 | MMP13 (0.54) | MMP13MMP2MAOBMAOAAPP | |
| SCHEMBL6377111 | 0.86 | MMP13 (0.70) | MMP13MMP2MAOBMAOANR4A2 | |
| SCHEMBL6378906 | 0.82 | MMP13 (0.90) | MMP13MMP2MAOBMAOAMMP14 | |
| SCHEMBL6377115 | 0.82 | MMP13 (0.90) | MMP13MMP2MMP14 | |
| SCHEMBL6377995 | 0.80 | MMP13 (0.60) | MMP13MMP2MAOBNR4A2PTPN1 | |
| SCHEMBL542505 | 0.78 | MEN1 (0.57) | MMP13MMP2MAOBMAOAAPP | |
| SCHEMBL10991891 | 0.74 | MAOB (0.80) | MAOBMAOAAPPNR4A2NPC1 | |
| SCHEMBL6378488 | 0.71 | MMP13 (0.56) | MMP13 | |
| SCHEMBL11600066 | 0.71 | MAOB (0.69) | MAOBMAOAAPPNR4A2NPC1 | |
| SCHEMBL3624903 | 0.71 | MAOB (0.69) | MAOBMAOAAPPNR4A2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202974-B1 | PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | PFIZER PROD INC (US) | 2005-11-09 | — | — | EP | disclosed |
| US-6579982-B1 | Treating inflammation, cancer | PFIZER INC. | 2003-06-17 | — | — | US | disclosed |