Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 5/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 4/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | FOXM1 | Q08050 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6381248 | 0.85 | MMP13 (0.48) | MMP13MAOBADAM17MMP2MMP14 | |
| SCHEMBL6382809 | 0.84 | MMP13 (0.53) | MMP13MAOBADAM17MMP2MMP14 | |
| SCHEMBL6375122 | 0.80 | MMP13 (0.43) | MMP13MAOBMAOAADAM17MMP2 | |
| SCHEMBL6383331 | 0.78 | MMP13 (0.54) | MMP13MAOBMAOAMMP2MMP14 | |
| SCHEMBL6377995 | 0.77 | MMP13 (0.60) | MMP13MAOBADAM17MMP2MMP14 | |
| SCHEMBL222118 | 0.72 | MMP13 (0.63) | MMP13MMP2MMP14 | |
| SCHEMBL6377947 | 0.72 | MMP13 (0.63) | MMP13MMP2MMP14 | |
| SCHEMBL6377111 | 0.70 | MMP13 (0.70) | MMP13MAOBMAOAADAM17MMP2 | |
| SCHEMBL6377105 | 0.68 | MMP14 (0.60) | MMP13MMP2MMP14 | |
| SCHEMBL6382057 | 0.68 | MMP13 (0.75) | MMP13MAOBMAOAMMP2MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202974-B1 | PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | PFIZER PROD INC (US) | 2005-11-09 | — | — | EP | disclosed |
| US-6579982-B1 | Treating inflammation, cancer | PFIZER INC. | 2003-06-17 | — | — | US | disclosed |