Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP14 | P50281 | 7/20 | 0.60 |
| ▸ | MMP13 | P45452 | 7/20 | 0.58 |
| ▸ | MMP2 | P08253 | 3/20 | 0.44 |
| ▸ | MMP9 | P14780 | 3/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | IL18 | Q14116 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6377577 | 0.81 | MMP2 (0.66) | MMP14MMP13MMP2MMP9MMP3 | |
| SCHEMBL6381224 | 0.81 | MMP13 (0.65) | MMP14MMP13MMP2MMP9MMP3 | |
| SCHEMBL222118 | 0.80 | MMP13 (0.63) | MMP14MMP13MMP2MMP9MMP3 | |
| SCHEMBL6378906 | 0.80 | MMP13 (0.90) | MMP14MMP13MMP2MMP9MMP3 | |
| SCHEMBL6377105 | 0.76 | MMP14 (0.60) | MMP14MMP13MMP2MMP9MMP3 | |
| SCHEMBL6391788 | 0.73 | MMP14 (0.93) | MMP14MMP13 | |
| SCHEMBL6379193 | 0.72 | MMP13 (0.66) | MMP14MMP13MMP2MMP9MMP3 | |
| SCHEMBL6379017 | 0.72 | MMP14 (0.62) | MMP14MMP13MMP2MMP9MMP3 | |
| SCHEMBL8852392 | 0.72 | PARP15 (0.63) | MMP3PARP15PARP10PARP2KDM4E | |
| SCHEMBL7041250 | 0.72 | PARP15 (0.63) | MMP3PARP15PARP10PARP2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202974-B1 | PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | PFIZER PROD INC (US) | 2005-11-09 | — | — | EP | disclosed |
| US-6579982-B1 | Treating inflammation, cancer | PFIZER INC. | 2003-06-17 | — | — | US | disclosed |