SCHEMBL6380480

SCHEMBL6380480

C[Si](C)(C)C#Cc1ccc(Br)cc1[N+](=O)[O-]

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
S100A4 P26447 1/20 0.40
TRPV1 Q8NER1 1/20 0.40
VCAM1 P19320 1/20 0.37
LMNA P02545 2/20 0.36
GPR35 Q9HC97 1/20 0.36
AAK1 Q2M2I8 1/20 0.35
IDO1 P14902 3/20 0.34
TDO2 P48775 2/20 0.34
GABRP O00591 1/20 0.34
GABRD O14764 1/20 0.34
GABRA1 P14867 1/20 0.34
GABRB1 P18505 1/20 0.34
GABRG2 P18507 1/20 0.34
GABRB3 P28472 1/20 0.34
GABRA5 P31644 1/20 0.34
GABRA3 P34903 1/20 0.34
GABRA2 P47869 1/20 0.34
GABRB2 P47870 1/20 0.34
GABRA4 P48169 1/20 0.34
GABRE P78334 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17875624 0.85 S100A4 (0.47) S100A4TRPV1VCAM1LMNAGPR35
SCHEMBL15218940 0.83 TSHR (0.53) VCAM1GPR35KDM4ESMN1; SMN2
SCHEMBL2107697 0.81 VCAM1 (0.37) VCAM1CYP1A2
SCHEMBL17875627 0.81 ALDH1A1 (0.51) VCAM1CYP1A2GAAMAPK1
SCHEMBL30413307 0.81 ALDH1A1 (0.51) VCAM1CYP1A2GAAMAPK1
SCHEMBL22658179 0.80 ALDH1A1 (0.39) S100A4TRPV1LMNAGPR35KDM4E
SCHEMBL709464 0.79 ALDH1A1 (0.42) TRPV1VCAM1LMNAGPR35KDM4E
SCHEMBL13931955 0.79 ALDH1A1 (0.47) KDM4ESMN1; SMN2MAPK1
SCHEMBL1796916 0.79 VCAM1 (0.53) VCAM1LMNAGAAMAPK1
SCHEMBL38666571 0.78 VCAM1 (0.39) VCAM1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1542869-A4 MOLECULAR SCALE ELECTRONIC DEVICES UNIV YALE (US) 2005-06-22 EP disclosed
EP-1542869-A2 MOLECULAR SCALE ELECTRONIC DEVICES Yale University (US) 2005-06-22 EP disclosed
US-20050101063-A1 Three-terminal field-controlled molecular devices TOUR JAMES M (US) 2005-05-12 US disclosed
US-6756605-B1 Molecular scale electronic devices YALE UNIVERSITY 2004-06-29 US disclosed
WO-2001027972-A9 MOLECULAR SCALE ELECTRONIC DEVICES UNIV YALE (US) 2002-11-14 WO disclosed
WO-2002035580-A2 THREE-TERMINAL FIELD-CONTROLLED MOLECULAR DEVICES MOLECULAR ELECTRONICS CORPORATION (US) 2002-05-02 WO disclosed
WO-2001027972-A2 MOLECULAR SCALE ELECTRONIC DEVICES YALE UNIVERSITY (US) 2001-04-19 WO disclosed