Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.46 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
| ▸ | RARB | P10826 | 7/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.39 |
| ▸ | RARA | P10276 | 2/20 | 0.39 |
| ▸ | RARG | P13631 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20503261 | 0.83 | KDM4E (0.45) | HCAR2HCAR3PPARARARBCNR1 | |
| SCHEMBL17288712 | 0.81 | KDM4E (0.46) | HCAR2HCAR3PPARACNR1CNR2 | |
| SCHEMBL2934234 | 0.76 | KDM4E (0.47) | HCAR2HCAR3MEN1ALDH1A1MAPT | |
| SCHEMBL9468599 | 0.76 | KDM5A (0.43) | HCAR2HCAR3PPARARARBCNR1 | |
| SCHEMBL4045930 | 0.71 | GRN (0.33) | ALDH1A1 | |
| SCHEMBL20503314 | 0.70 | LMNA (0.44) | PPARACNR2MEN1MAPTKMT2A | |
| SCHEMBL1017 | 0.69 | GRN (0.43) | HCAR2HCAR3GPR35ALDH1A1MAPT | |
| SCHEMBL27694050 | 0.69 | POLB (0.48) | PPARACNR1CNR2 | |
| SCHEMBL28251767 | 0.68 | ALDH1A1 (0.41) | HCAR2ALDH1A1 | |
| SCHEMBL11116628 | 0.67 | RARB (0.49) | HCAR2HCAR3PPARARARBRARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551403-A1 | 5-SUBSTITUTED 2H-PYRAZONE-3-CARBOXYLIC ACID DERIVATIVES AS ANTILIPOLYTIC AGENTS FOR THE TREATMENT OF METABOLIC-RELATED DISORDERS SUCH AS DYSLIPIDEMIA | Arena Pharmaceuticals, Inc. (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004032928-A1 | 5-SUBSTITUTED 2H-PYRAZONE-3-CARBOXYLIC ACID DERIVATIVES AS ANTILIPOLYTIC AGENTS FOR THE TREATMENT OF METABOLIC-RELATED DISORDERS SUCH AS DYSLIPIDEMIA | ARENA PHARMACEUTICALS, INC. (US) | 2004-04-22 | — | — | WO | disclosed |