Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 6/20 | 0.45 |
| ▸ | PARP15 | Q460N3 | 6/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 6/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6378041 | 0.94 | MMP13 (0.54) | MMP13HPGDPARP15PARP10PARP2 | |
| SCHEMBL6376216 | 0.94 | MMP13 (0.54) | MMP13HPGDPARP15PARP10PARP2 | |
| SCHEMBL6383266 | 0.86 | MMP13 (0.51) | MMP13HPGDTDP1 | |
| SCHEMBL6377111 | 0.73 | MMP13 (0.70) | MMP13HPGD | |
| SCHEMBL29024848 | 0.73 | PARP15 (0.64) | PARP15PARP10PARP2TDP1SIGMAR1 | |
| SCHEMBL6378455 | 0.72 | MMP14 (0.60) | MMP13PARP15PARP10PARP2 | |
| SCHEMBL6382057 | 0.71 | MMP13 (0.75) | MMP13 | |
| SCHEMBL6383331 | 0.71 | MMP13 (0.54) | MMP13PARP10 | |
| SCHEMBL6381224 | 0.70 | MMP13 (0.65) | MMP13 | |
| SCHEMBL6377577 | 0.70 | MMP2 (0.66) | MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202974-B1 | PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | PFIZER PROD INC (US) | 2005-11-09 | — | — | EP | disclosed |