Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 3/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.34 |
| ▸ | PPARG | P37231 | 7/20 | 0.34 |
| ▸ | PPARD | Q03181 | 7/20 | 0.34 |
| ▸ | PPARA | Q07869 | 7/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.34 |
| ▸ | TSHR | P16473 | 4/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TLR2 | O60603 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | FABP4 | P15090 | 2/20 | 0.34 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.34 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6381319 | 0.98 | CETP (0.39) | CETPGPR84PPARGPPARDPPARA | |
| SCHEMBL6381906 | 0.95 | CETP (0.37) | CETPAKR1B1GPR84PPARGPPARD | |
| SCHEMBL6386232 | 0.88 | CETP (0.33) | CETP | |
| SCHEMBL6386119 | 0.80 | FFAR3 (0.34) | CETP | |
| SCHEMBL787052 | 0.78 | AKR1B1 (0.41) | AKR1B1GPR84PPARGPPARDPPARA | |
| SCHEMBL23533401 | 0.76 | GPR84 (0.43) | GPR84PPARGPPARDPPARAHDAC11 | |
| SCHEMBL2051592 | 0.76 | GPR84 (0.43) | GPR84PPARGPPARDPPARAHDAC11 | |
| SCHEMBL222063 | 0.76 | GPR84 (0.43) | GPR84PPARGPPARDPPARAHDAC11 | |
| Hydrochloric Acid SCHEMBL11248003 | 0.76 | AKR1B1 (0.39) | AKR1B1GPR84PPARGPPARDPPARA | |
| SCHEMBL3493870 | 0.76 | GPR84 (0.43) | GPR84PPARGPPARDPPARAHDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050113447-A1 | Selective retinoid agonists | BELLONI PAULA N (US) | 2005-05-26 | — | — | US | disclosed |
| US-6828337-B2 | Bicyclic retinods containing ester or acid group; useful for treating emphysema | HOFFMANN-LA ROCHE INC. | 2004-12-07 | — | — | US | disclosed |
| EP-1206436-B1 | RETINOIDS FOR THE TREATMENT OF EMPHYSEMA | HOFFMANN LA ROCHE (CH) | 2004-10-13 | — | — | EP | disclosed |
| US-20030176726-A1 | Bicyclic retinods containing ester or acid group; useful for treating emphysema | HOFFMANN-LA ROCHE INC. | 2003-09-18 | — | — | US | disclosed |
| US-6528677-B1 | Such as 4-(4,4,7,7-tetramethyl-2-pentyl-2,3,4,5,6,7-hexa-hydro-1H-indene-2 -ylethynyl)-benzoic acid; emphysema | HOFFMANN-LA ROCHE INC. | 2003-03-04 | — | — | US | disclosed |
| EP-1206436-A2 | RETINOIDS FOR THE TREATMENT OF EMPHYSEMA | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001009076-A2 | RETINOIDS FOR THE TREATMENT OF EMPHYSEMA | F. HOFFMANN-LA ROCHE AG (CH) | 2001-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030176726-A1 | Bicyclic retinods containing ester or acid group; useful for treating emphysema | RARG, RXRA, RXRG | CETP 634/4885AKR1B1 304/4885GPR84 110/4885 |
| US-20050113447-A1 | Selective retinoid agonists | RARA, RARB, RARG | CETP 1857/4885AKR1B1 410/4885GPR84 64/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.