SCHEMBL787052

SCHEMBL787052

CCCCCC1(C(=O)O)CC1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1B1 P15121 1/20 0.41
GPR84 Q9NQS5 7/20 0.39
PPARG P37231 7/20 0.39
PPARD Q03181 7/20 0.39
PPARA Q07869 7/20 0.39
HDAC11 Q96DB2 5/20 0.39
TSHR P16473 4/20 0.39
PTPN1 P18031 3/20 0.39
ALDH1A1 P00352 2/20 0.39
TLR2 O60603 2/20 0.39
TDP1 Q9NUW8 2/20 0.39
FABP4 P15090 2/20 0.39
SLC22A6 Q4U2R8 1/20 0.39
SLC22A8 Q8TCC7 1/20 0.39
MEN1 O00255 1/20 0.39
ESR1 P03372 1/20 0.39
ALOX15 P16050 1/20 0.39
PDE4A P27815 1/20 0.39
KMT2A Q03164 1/20 0.39
PDE3A Q14432 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31124105 0.98 GPR84 (0.43) GPR84PPARGPPARDPPARAHDAC11
SCHEMBL31124156 0.98 GPR84 (0.43) GPR84PPARGPPARDPPARAHDAC11
Hydrochloric Acid SCHEMBL11248003 0.98 AKR1B1 (0.39) AKR1B1GPR84PPARGPPARDPPARA
SCHEMBL3493870 0.98 GPR84 (0.43) GPR84PPARGPPARDPPARAHDAC11
SCHEMBL31124096 0.98 GPR84 (0.43) GPR84PPARGPPARDPPARAHDAC11
SCHEMBL23533401 0.98 GPR84 (0.43) GPR84PPARGPPARDPPARAHDAC11
SCHEMBL11292271 0.98 GPR84 (0.43) GPR84PPARGPPARDPPARAHDAC11
SCHEMBL2051592 0.98 GPR84 (0.43) GPR84PPARGPPARDPPARAHDAC11
SCHEMBL222063 0.98 GPR84 (0.43) GPR84PPARGPPARDPPARAHDAC11
SCHEMBL31157047 0.98 GPR84 (0.43) GPR84PPARGPPARDPPARAHDAC11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8853390-B2 Processes for preparing 1,2-substituted cyclopropyl derivatives ABBVIE INC. (US) 2014-10-07 US claimed
US-20120071651-A1 Processes for Preparing 1,2-Substituted Cyclopropyl Derivatives ABBOTT LABORATORIES (US) 2012-03-22 US claimed
WO-2012037258-A1 PROCESSES FOR PREPARING 1,2-SUBSTITUTED CYCLOPROPYL DERIVATIVES ABBOTT LABORATORIES (US) 2012-03-22 WO claimed
US-20090312558-A1 PROCESS FOR THE PREPARATION OF ARYLCYCLOPROPOANE CARBOXYLIC CARBONITRILES, AND COMPOUNDS DERIVED THEREFROM RELIANCE LIFE SCIENCES PVT. LTD. (IN) 2009-12-17 US claimed
WO-2009150660-A1 A PROCESS FOR THE PREPARATION OF ARYLCYCLOPROPANE CARBOXYLIC CARBONITRILES, AND COMPOUNDS DERIVED THEREFROM RELIANCE LIFE SCIENCES PVT. LTD. (IN) 2009-12-17 WO claimed
US-6613935-B2 Reacting a beta-ketoester derivative such as an acetoacetate with 1,2-dichloroethane that is readily available at low cost DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2003-09-02 US claimed
EP-1300389-A2 Process for producing 1-acyl-1-cyclopropanecarboxylate derivatives Daicel Chemical Industries, Ltd. (JP) 2003-04-09 EP claimed
US-20030065212-A1 Process for producing 1-acyl-1-cyclopropanecarboxylate derivatives DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2003-04-03 US claimed
EP-0043492-B1 1-ARYL-CYCLOPROPANE-1-CARBOXYLIC-ACID ESTERS, THEIR PREPARATION AND THEIR USE AS INSECTICIDES BAYER AG (DE) 1983-10-05 EP claimed
JP-10165132-A None JP disclosed
EP-4692041-A1 METHOD FOR PRODUCING BIO-DERIVED ESTER COMPOUND, BIO-DERIVED ESTER COMPOUND PRODUCED THEREBY, COSMETIC OR DETERGENT CONTAINING BIO-DERIVED ESTER COMPOUND, AND METHOD FOR REDUCING ODOR OF ESTER COMPOUND ADEKA CORPORATION (JP) 2026-02-11 EP disclosed
WO-2024204392-A1 METHOD FOR PRODUCING BIO-DERIVED ESTER COMPOUND, BIO-DERIVED ESTER COMPOUND PRODUCED THEREBY, COSMETIC OR DETERGENT CONTAINING BIO-DERIVED ESTER COMPOUND, AND METHOD FOR REDUCING ODOR OF ESTER COMPOUND 株式会社ADEKA 2024-10-03 WO disclosed
CN-112312902-B Pd (II) -catalyzed enantioselective C-H arylation of free carboxylic acids 斯克里普斯研究学院 2022-02-18 CN disclosed
US-11021427-B2 Pd(II)-catalyzed enantioselective C—H arylation of free carboxylic acids THE SCRIPPS RESEARCH INSTITUTE (US) 2021-06-01 US disclosed
WO-1999019970-A1 A STATOR AND A METHOD FOR MANUFACTURING A STATOR ABB AB (SE) 1999-04-22 WO disclosed
WO-1999017428-A1 METHOD AND ARRANGEMENT FOR EARTHING A ROTATING ELECTRIC MACHINE, AND A ROTATING ELECTRIC MACHINE ABB AB (SE) 1999-04-08 WO disclosed
WO-1998034325-A1 A DEVICE IN THE STATOR OF A ROTATING ELECTRIC MACHINE ASEA BROWN BOVERI AB (SE) 1998-08-06 WO disclosed
WO-1998034243-A1 A MECHANICALLY SUPPORTED WINDING ASEA BROWN BOVERI AB (SE) 1998-08-06 WO disclosed
JP-H10165132-A AROMA COMPOSITION FOR FOOD SHIONO KORYO KK 1998-06-23 JP disclosed
US-4360690-A Combating pests with 1-aryl-cyclopropane-1-carboxylic acid esters BAYER AKTIENGESELLSCHAFT (DE) 1982-11-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090312558-A1 PROCESS FOR THE PREPARATION OF ARYLCYCLOPROPOANE CARBOXYLIC CARBONITRILES, AND COMPOUNDS DERIVED THEREFROM NOTUM, SULT2A1, SULT1A1 AKR1B1 1085/4885GPR84 1977/4885PPARG 1808/4885
US-11021427-B2 Pd(II)-catalyzed enantioselective C—H arylation of free carboxylic acids PDCD1, PDK3, PDCD1LG2 AKR1B1 558/4885GPR84 1532/4885PPARG 120/4885
US-20120071651-A1 Processes for Preparing 1,2-Substituted Cyclopropyl Derivatives HRH3, HRH4, HRH1 AKR1B1 658/4885GPR84 123/4885PPARG 4304/4885
US-20030065212-A1 Process for producing 1-acyl-1-cyclopropanecarboxylate derivatives DHCR24, CYP1A1, CYP51A1 AKR1B1 35/4885GPR84 2518/4885PPARG 2430/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.