Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 4/20 | 0.51 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MMP14 | P50281 | 2/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6378488 | 0.86 | MMP13 (0.56) | MMP13HPGDTDP1 | |
| SCHEMBL6376216 | 0.84 | MMP13 (0.54) | MMP13MAOAMAOBHPGDTDP1 | |
| SCHEMBL6378041 | 0.84 | MMP13 (0.54) | MMP13MAOAMAOBMMP2HPGD | |
| SCHEMBL25975202 | 0.70 | APP (0.41) | MAOAMAOBTDP1 | |
| SCHEMBL27038617 | 0.70 | KDM4E (0.46) | TDP1 | |
| SCHEMBL10267768 | 0.70 | DRD4 (0.48) | HPGD | |
| SCHEMBL12050033 | 0.70 | CARM1 (0.53) | TDP1GRM2 | |
| SCHEMBL6377111 | 0.70 | MMP13 (0.70) | MMP13MAOAMAOBMMP2HPGD | |
| SCHEMBL6378455 | 0.68 | MMP14 (0.60) | MMP13MMP2MMP3MMP9LMNA | |
| SCHEMBL26075687 | 0.68 | PARP10 (0.69) | MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202974-B1 | PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | PFIZER PROD INC (US) | 2005-11-09 | — | — | EP | disclosed |
| US-6579982-B1 | Treating inflammation, cancer | PFIZER INC. | 2003-06-17 | — | — | US | disclosed |