Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 6/20 | 0.51 |
| ▸ | PDE1B | Q01064 | 6/20 | 0.51 |
| ▸ | PDE1C | Q14123 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6388357 | 0.88 | ALPL (0.45) | PDE1APDE1BPDE1CKDM4EHPGD | |
| SCHEMBL6230583 | 0.77 | NR4A2 (0.52) | ALOX15NR4A2 | |
| SCHEMBL6233791 | 0.77 | NR4A2 (0.52) | ALOX15NR4A2 | |
| SCHEMBL6390088 | 0.74 | TSHR (0.39) | PDE1APDE1BPDE1CKDM4EHPGD | |
| SCHEMBL5757658 | 0.74 | PTGS2 (0.58) | KDM4EHPGDLMNAMAPTMAPK1 | |
| SCHEMBL8587962 | 0.69 | ALDH1A1 (0.45) | ALDH1A1LMNAMAPTALOX15NR4A2 | |
| SCHEMBL6594963 | 0.69 | PTGS2 (0.57) | KDM4EHPGDHSD17B10LMNAMAPT | |
| SCHEMBL25212344 | 0.67 | NR4A2 (0.52) | ALOX15NR4A2 | |
| SCHEMBL5056065 | 0.67 | AKR1C3 (0.74) | DRD2DRD3 | |
| SCHEMBL25197469 | 0.66 | NR4A2 (0.51) | ALOX15NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050124622-A1 | Compounds and methods for the treatment of pain | BROWN DEAN G (US) | 2005-06-09 | — | — | US | disclosed |
| EP-1244661-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001047926-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2001-07-05 | — | — | WO | disclosed |