Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | MAP2 | P11137 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | MAT2A | P31153 | 2/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5757658 | 0.82 | PTGS2 (0.58) | PTGS2MAPTHRH4HRH3MAP2 | |
| SCHEMBL6994667 | 0.74 | HRH4 (0.64) | PTGS2HRH4HRH3MAT2ACA12 | |
| SCHEMBL10857861 | 0.72 | PTGS2 (0.49) | PTGS2MAPTHRH4HRH3MAT2A | |
| SCHEMBL6388357 | 0.69 | ALPL (0.45) | PTGS2ALOX5KDM4EHPGDMAPK1 | |
| SCHEMBL6384274 | 0.69 | PDE1A (0.51) | PTGS2MAPTKDM4EHSD17B10LMNA | |
| SCHEMBL14543827 | 0.66 | PARP1 (0.62) | MAT2ACA12CA9KDM4EMEN1 | |
| SCHEMBL2730991 | 0.66 | PTGS2 (0.52) | PTGS2MAPTMAP2ALOX5KDM4E | |
| SCHEMBL602787 | 0.65 | HRH4 (0.62) | PTGS2HRH4HRH3MAP2ALOX5 | |
| SCHEMBL24196838 | 0.63 | ALDH1A1 (0.49) | PTGS2MAPTHRH4MAP2MEN1 | |
| SCHEMBL29586144 | 0.63 | PARP1 (0.58) | MAT2ACA12CA9KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244663-B1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2004-08-25 | — | — | EP | disclosed |