Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 10/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KDM6B | O15054 | 5/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.42 |
| ▸ | KDM4D | Q6B0I6 | 3/20 | 0.41 |
| ▸ | KDM4A | O75164 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6386775 | 0.83 | TSHR (0.49) | NOTUMALDH1A1KDM4ESGMS2MEN1 | |
| SCHEMBL10751618 | 0.83 | KDM4C (0.56) | KDM4CKDM6BTDP1ALDH1A1KDM4D | |
| SCHEMBL9644380 | 0.82 | FOLH1 (0.61) | HTTFOLH1ALDH1A1SLC16A3KDM4E | |
| SCHEMBL6390426 | 0.82 | KDM4C (0.43) | KDM4CKDM6BTDP1FOLH1ALDH1A1 | |
| SCHEMBL21983945 | 0.80 | TAAR1 (0.50) | NOTUMHTTALDH1A1KDM4ENR3C2 | |
| SCHEMBL258369 | 0.79 | KDM4C (0.51) | KDM4CKDM6BTDP1SIRT3ALDH1A1 | |
| SCHEMBL258224 | 0.78 | KDM6B (0.59) | KDM4CKDM6BTDP1ALDH1A1KDM4D | |
| Hydrochloric Acid SCHEMBL5739434 | 0.78 | KDM4C (0.50) | KDM4CKDM6BTDP1SIRT3ALDH1A1 | |
| SCHEMBL9858541 | 0.77 | KDM4C (0.47) | KDM4CKDM6BTDP1SIRT3FOLH1 | |
| SCHEMBL123203 | 0.77 | KDM4C (0.51) | KDM4CKDM6BTDP1SIRT3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050245503-A1 | Therapeutic heterocycles | ASTRAZENECA AB (SE) | 2005-11-03 | — | — | US | disclosed |
| EP-1458684-A2 | THERAPEUTIC HETEROCYCLES | AstraZeneca AB (SE) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003051276-A2 | THERAPEUTIC HETEROCYCLES | ASTRAZENECA AB (SE) | 2003-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245503-A1 | Therapeutic heterocycles | OPRK1, RECQL, OPRM1 | KDM4C 1795/4885NOTUM 4701/4885HTT 669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.