Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPD1 | P10809 | 1/20 | 0.65 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.63 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.63 |
| ▸ | INSR | P06213 | 3/20 | 0.60 |
| ▸ | IGF1R | P08069 | 3/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.59 |
| ▸ | GSK3B | P49841 | 2/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | CLK1 | P49759 | 1/20 | 0.53 |
| ▸ | CLK2 | P49760 | 1/20 | 0.53 |
| ▸ | CLK3 | P49761 | 1/20 | 0.53 |
| ▸ | MELK | Q14680 | 1/20 | 0.53 |
| ▸ | NAT1 | P18440 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6388201 | 1.00 | HSPD1 (0.65) | HSPD1HSPE1PDE4BPDE3AINSR | |
| SCHEMBL13855592 | 0.91 | HSPD1 (0.62) | HSPD1HSPE1PDE4BPDE3AINSR | |
| SCHEMBL3896735 | 0.90 | HSPD1 (0.61) | HSPD1HSPE1PDE4BPDE3AINSR | |
| SCHEMBL3896737 | 0.90 | HSPD1 (0.61) | HSPD1HSPE1PDE4BPDE3AINSR | |
| SCHEMBL1082925 | 0.90 | PIK3CG (0.71) | PDE4BINSRIGF1RPIK3CGMEN1 | |
| SCHEMBL1082924 | 0.90 | PIK3CG (0.71) | PDE4BINSRIGF1RPIK3CGMEN1 | |
| SCHEMBL3895207 | 0.87 | GSK3B (0.67) | HSPD1HSPE1PDE4BPDE3AINSR | |
| SCHEMBL8338948 | 0.87 | HSPD1 (0.57) | HSPD1HSPE1PDE4BPDE3AINSR | |
| SCHEMBL5164183 | 0.87 | GSK3B (0.67) | HSPD1HSPE1PDE4BPDE3AINSR | |
| SCHEMBL3895202 | 0.87 | GSK3B (0.67) | HSPD1HSPE1PDE4BPDE3AINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050042674-A9 | Common ligand mimics: thiazolidinediones and rhodanines | TRIAD THERAPEUTICS, INC. | 2005-02-24 | — | — | US | disclosed |
| US-20040009526-A1 | Common ligand mimics: thiazolidinediones and rhodanines | YU LIN (US) | 2004-01-15 | — | — | US | disclosed |
| WO-2003072033-A2 | COMMON LIGAND MIMICS: THIAZOLIDINEDIONES AND RHODANINES | TRIAD THERAPEUTICS, INC. (US) | 2003-09-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040009526-A1 | Common ligand mimics: thiazolidinediones and rhodanines | GPR65, NR2E3, FGFR3 | HSPD1 1453/4885HSPE1 1483/4885PDE4B 3419/4885 |
| US-20050042674-A9 | Common ligand mimics: thiazolidinediones and rhodanines | GPR65, NR2E3, FGFR3 | HSPD1 1453/4885HSPE1 1483/4885PDE4B 3419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.