Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.61 |
| ▸ | CA12 | O43570 | 1/20 | 0.61 |
| ▸ | CA1 | P00915 | 1/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.61 |
| ▸ | CA3 | P07451 | 1/20 | 0.61 |
| ▸ | CA4 | P22748 | 1/20 | 0.61 |
| ▸ | CA9 | Q16790 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.61 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.58 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.54 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL374785 | 1.00 | CA2 (0.61) | CA2CA12CA1GLACA3 | |
| Glutarate SCHEMBL28110215 | 0.90 | HDAC3 (0.58) | CA2CA12CA1GLACA3 | |
| Glutarate SCHEMBL379351 | 0.90 | HDAC3 (0.58) | CA2CA12CA1GLACA3 | |
| Adipic Acid SCHEMBL523364 | 0.90 | HDAC3 (0.59) | CA2CA12CA1GLACA3 | |
| Sebacic Acid SCHEMBL28538398 | 0.87 | HDAC3 (0.63) | CA2CA12CA1GLACA3 | |
| Azelaic Acid SCHEMBL28109737 | 0.87 | HDAC3 (0.63) | CA2CA12CA1GLACA3 | |
| Phenol SCHEMBL4623314 | 0.87 | HDAC3 (0.63) | CA2CA12CA1GLACA3 | |
| Phenol SCHEMBL2369589 | 0.85 | HDAC3 (0.59) | CA2CA12CA1GLACA3 | |
| Phenol SCHEMBL28036694 | 0.85 | CA2 (0.50) | CA2CA12CA1GLACA3 | |
| Succinic Acid SCHEMBL8655758 | 0.84 | ALDH1A1 (0.60) | CA2CA12CA1CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108530414-A | A kind of method and its heating system preparing tocopherol succinate | 江苏科鼐生物制品有限公司 | 2018-09-14 | — | — | CN | claimed |
| CN-105412024-B | Target hydrophobic anticancer drug nanometer formulation and preparation method thereof | 广州帝奇医药技术有限公司 | 2018-03-30 | — | — | CN | claimed |
| CN-107669632-A | A kind of pharmaceutical carrier, micella, antitumor and antitumor cell diversion medicaments preparation, and its production and use | 四川大学 | 2018-02-09 | — | — | CN | claimed |
| CN-107233348-A | A kind of bufotalin nanocrystal and preparation method thereof | 宁夏医科大学 | 2017-10-10 | — | — | CN | claimed |
| CN-1216993-A | alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL INC (US) | 1999-05-19 | — | — | CN | claimed |
| CN-212701524-U | Raw material mixing device for preparing natural tocopherol succinate | 江苏科鼐生物制品有限公司 | 2021-03-16 | — | — | CN | disclosed |
| CN-105849162-B | Improvements in matrix additives | 赫克塞尔合成有限公司 | 2019-11-15 | — | — | CN | disclosed |
| CN-110215451-A | Hybridize paper mulberry alcohol composition and its application | 兰溪市立顺生物有限公司 | 2019-09-10 | — | — | CN | disclosed |
| CN-110101079-A | Alimentation composition and application thereof containing magnesium threonate | MJN 美国控股有限责任公司 | 2019-08-09 | — | — | CN | disclosed |
| CN-105228470-B | Vitamin E soluble derivative preparation and composition comprising it | 维尔恩公司 | 2019-05-31 | — | — | CN | disclosed |
| CN-109803671-A | Topical pharmaceutical composition for promoting hair growth and reducing hair loss | 哈比尔·F·赫拉基瓦拉 | 2019-05-24 | — | — | CN | disclosed |
| CN-109475635-A | Method for treating obesity | 玛丽女王伦敦大学 | 2019-03-15 | — | — | CN | disclosed |
| CN-105960397-A | Tablet formulations of CGRP-active compounds | 默沙东公司 | 2016-09-21 | — | — | CN | disclosed |
| CN-103987278-B | Nutritional phytonutrient composition | MJN 美国控股有限责任公司 | 2016-08-17 | — | — | CN | disclosed |
| CN-105849162-A | Improvements in matrix additives | 赫克塞尔合成有限公司 | 2016-08-10 | — | — | CN | disclosed |
| CN-103520150-A | Medical application of vitamin E and vitamin E derivatives serving as G-CSF (granulocyte colony-stimulating factor) secretion inductive agent and cell mobilization agent | INST RADIATION MED AMMS PLA | 2014-01-22 | — | — | CN | disclosed |
| JP-2005307396-A | FLAME-RETARDANT FINISHING AGENT OF POLYESTER-BASED FIBER PRODUCT AND FLAME-RETARDANT FINISHING METHOD | DAIKYO KAGAKU KK | 2005-11-04 | — | — | JP | disclosed |
| CN-1216993-A | alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL INC (US) | 1999-05-19 | — | — | CN | disclosed |
| CN-1155684-A | Toner for developing electrostatic image | CANON KK (JP) | 1997-07-30 | — | — | CN | disclosed |
| US-4308180-A | TIRE TREADS | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1981-12-29 | — | — | US | disclosed |