Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 19/20 | 0.76 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2730559 | 0.87 | TRPM8 (0.82) | TRPM8 | |
| SCHEMBL21955512 | 0.87 | TRPM8 (0.81) | TRPM8LMNA | |
| SCHEMBL30828336 | 0.87 | TRPM8 (0.81) | TRPM8LMNA | |
| SCHEMBL20640704 | 0.87 | TRPM8 (1.00) | TRPM8LMNA | |
| SCHEMBL18690998 | 0.87 | TRPM8 (0.81) | TRPM8 | |
| SCHEMBL2729241 | 0.87 | TRPM8 (1.00) | TRPM8 | |
| SCHEMBL18706655 | 0.86 | TRPM8 (0.83) | TRPM8LMNATDP1 | |
| SCHEMBL20640720 | 0.85 | TRPM8 (0.81) | TRPM8LMNA | |
| SCHEMBL30828335 | 0.85 | TRPM8 (0.81) | TRPM8LMNA | |
| SCHEMBL18199129 | 0.85 | TRPM8 (0.71) | TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061698-A9 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. (US) | 2012-09-13 | — | — | WO | disclosed |
| WO-2012061698-A2 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. (US) | 2012-05-10 | — | — | WO | disclosed |