Sugi Predict

Sugi Predict / Compounds / SCHEMBL639911

SCHEMBL639911

SCHEMBL639911

O=C(O)N1CCC(N2CCNCC2)CC1

nearest known ligand 0.50

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL3 Q96JM7 12/20 0.46
▸ L3MBTL1 Q9Y468 10/20 0.46
▸ CHRNB2 P17787 1/20 0.44
▸ CHRNA3 P32297 1/20 0.44
▸ CHRNA4 P43681 1/20 0.44
▸ CHRNB3 Q05901 1/20 0.44
▸ CHRNA6 Q15825 1/20 0.44
▸ HPGD P15428 1/20 0.42
▸ KMT2A Q03164 1/20 0.42
▸ SMN1; SMN2 Q16637 1/20 0.42
▸ MBTD1 Q05BQ5 4/20 0.41
▸ TP53BP1 Q12888 2/20 0.41
▸ L3MBTL4 Q8NA19 1/20 0.41
▸ HRH3 Q9Y5N1 1/20 0.39
▸ HTR6 P50406 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21070056 0.89 L3MBTL3 (0.41) L3MBTL3L3MBTL1CHRNB2CHRNA3CHRNA4
SCHEMBL23788123 0.89 L3MBTL3 (0.41) L3MBTL3L3MBTL1CHRNB2CHRNA3CHRNA4
SCHEMBL29579349 0.86 CACNA2D1 (0.40) L3MBTL3L3MBTL1CHRNB2CHRNA3CHRNA4
SCHEMBL23301799 0.85 HTR6 (0.50) L3MBTL3L3MBTL1CHRNB2CHRNA3CHRNA4
SCHEMBL517371 0.84 HRH3 (0.45) L3MBTL3L3MBTL1CHRNB2CHRNA3CHRNA4
SCHEMBL2550326 0.83 L3MBTL3 (0.46) L3MBTL3L3MBTL1MBTD1TP53BP1L3MBTL4
SCHEMBL1400926 0.82 L3MBTL3 (0.45) L3MBTL3L3MBTL1CHRNB2CHRNA3CHRNA4
SCHEMBL20808277 0.82 L3MBTL3 (0.45) L3MBTL3L3MBTL1CHRNB2CHRNA3CHRNA4
SCHEMBL4541398 0.82 CHRNB2 (0.41) L3MBTL3L3MBTL1CHRNB2CHRNA3CHRNA4
SCHEMBL2862492 0.81 L3MBTL3 (0.58) L3MBTL3L3MBTL1KMT2AMBTD1TP53BP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE39707-E1 Camptothecin derivatives CATHOLIC HEALTHCARE WEST (US) 2007-06-26 — — US claimed
WO-2023156791-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR TREATING A ERK5-MEDIATED DISEASE CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2023-08-24 — — WO disclosed
WO-2015086693-A1 PYRAZOLOPYRIMIDIN-2-YL DERIVATIVES AS JAK INHIBITORS ALMIRALL, S.A. (ES) 2015-06-18 — — WO disclosed
EP-2850075-A1 PIPERAZINE-PIPERIDINE COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS Theravance Biopharma R&D IP, LLC (US) 2015-03-25 — — EP disclosed
US-8791148-B2 Substituted benzimidazolone derivatives, medicaments comprising them and their use AbbVie Deutschland GmbH & Co. KG (DE) 2014-07-29 — — US disclosed
WO-2013163262-A1 PIPERAZINE-PIPERIDINE COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS THERAVANCE, INC. (US) 2013-10-31 — — WO disclosed
US-20120172335-A1 SUBSTITUTED BENZIMIDAZOLONE DERIVATIVES, MEDICAMENTS COMPRISING THEM AND THEIR USE ABBVIE DEUTSCHLAND GMBH & CO KG (DE) 2012-07-05 — — US disclosed
US-8158809-B2 Podophyllotoxin derivatives SUTTER WEST BAY HOSPITALS (US) 2012-04-17 — — US disclosed
US-8119676-B2 Substituted benzimidazolone derivatives, medicaments comprising them and their use Abbott GmbH & Co. HG (DE) 2012-02-21 — — US disclosed
US-20100152168-A1 SUBSTITUTED BENZIMIDAZOLONE DERIVATIVES, MEDICAMENTS COMPRISING THEM AND THEIR USE ABBOTT GMBH & CO. KG (DE) 2010-06-17 — — US disclosed
US-20090298870-A1 PODOPHYLLOTOXIN DERIVATIVES Sutter West Bay Hospitals, dba California Pacific Medical Center and Catholic Healthcare West 2009-12-03 — — US disclosed
US-7605262-B2 Podophyllotoxin derivatives SUTTER WEST BAY HOSPITALS (US) 2009-10-20 — — US disclosed
EP-2061769-A1 SUBSTITUTED BENZIMIDAZOLONE DERIVATIVES, MEDICAMENTS COMPRISING THEM AND THEIR USE Abbott GmbH & Co. KG (DE) 2009-05-27 — — EP disclosed
US-7538111-B2 Benzenesulphonamide derivatives, method for production and use thereof for treatment of pain LABORATOIRES FOURNIER S.A. (FR) 2009-05-26 — — US disclosed
US-20080113941-A1 Podophyllotoxin Derivatives CALIFORNIA PACIFIC MEDICAL CENTER 2008-05-15 — — US disclosed
WO-2008025736-A1 SUBSTITUTED BENZIMIDAZOLONE DERIVATIVES, MEDICAMENTS COMPRISING THEM AND THEIR USE ABBOTT GMBH & CO. KG (DE) 2008-03-06 — — WO disclosed
US-20060178360-A1 Benzenesulphonamide derivatives, method for production and use thereof for treatment of pain LABORATOIRES FOURNIER S.A. (FR) 2006-08-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060178360-A1 Benzenesulphonamide derivatives, method for production and use thereof for treatment of pain LTB4R2, BDKRB2, TBXA2R L3MBTL3 4412/4885L3MBTL1 4617/4885CHRNB2 1984/4885
US-20080113941-A1 Podophyllotoxin Derivatives APEH, DAGLA, DPY30 L3MBTL3 382/4885L3MBTL1 274/4885CHRNB2 2822/4885
US-20100152168-A1 SUBSTITUTED BENZIMIDAZOLONE DERIVATIVES, MEDICAMENTS COMPRISING THEM AND THEIR USE AVPR2, AVPR1B, AVPR1A L3MBTL3 3577/4885L3MBTL1 3180/4885CHRNB2 3374/4885
US-20120172335-A1 SUBSTITUTED BENZIMIDAZOLONE DERIVATIVES, MEDICAMENTS COMPRISING THEM AND THEIR USE AVPR2, AVPR1B, AVPR1A L3MBTL3 3577/4885L3MBTL1 3180/4885CHRNB2 3374/4885
US-20090298870-A1 PODOPHYLLOTOXIN DERIVATIVES APEH, DAGLA, DPY30 L3MBTL3 382/4885L3MBTL1 274/4885CHRNB2 2822/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.