Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 4/20 | 0.58 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.58 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.58 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGAV | P06756 | 1/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6151068 | 1.00 | ITGB1 (0.58) | ITGB1ITGA4ITGA2FKBP1AMAPK1 | |
| SCHEMBL8248902 | 0.90 | ITGB1 (0.51) | ITGB1ITGA4ITGA2ITGA5ITGB3 | |
| SCHEMBL4259952 | 0.90 | ITGB1 (0.51) | ITGB1ITGA4ITGA2ITGA5ITGB3 | |
| SCHEMBL5491587 | 0.89 | FKBP1A (0.54) | ITGB1ITGA4ITGA2FKBP1AMAPK1 | |
| SCHEMBL5495223 | 0.89 | FKBP1A (0.54) | ITGB1ITGA4ITGA2FKBP1AMAPK1 | |
| SCHEMBL5496781 | 0.87 | ITGA4 (0.56) | ITGB1ITGA4ITGA2FKBP1AMAPK1 | |
| SCHEMBL6406608 | 0.86 | ITGB1 (0.57) | ITGB1ITGA4ITGA2 | |
| SCHEMBL6406612 | 0.86 | ITGB1 (0.57) | ITGB1ITGA4ITGA2 | |
| SCHEMBL5499020 | 0.85 | ITGA4 (0.56) | ITGB1ITGA4ITGA2FKBP1AMAPK1 | |
| SCHEMBL5488891 | 0.85 | FKBP1A (0.51) | ITGB1ITGA4ITGA2FKBP1AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050143391-A1 | Heterocyclic amides with alpha-4 integrin antagonist activity | J. Uriach Y Compañia S.A. (ES) | 2005-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143391-A1 | Heterocyclic amides with alpha-4 integrin antagonist activity | ITGB4, ITGA4, ITGA1 | ITGB1 4/4885ITGA4 2/4885ITGA2 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.