Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.95 |
| ▸ | GLA | P06280 | 1/20 | 0.95 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.64 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.64 |
| ▸ | RECQL | P46063 | 2/20 | 0.64 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.64 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.64 |
| ▸ | F3 | P13726 | 2/20 | 0.64 |
| ▸ | TNKS | O95271 | 1/20 | 0.64 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.64 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.64 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butenone SCHEMBL792625 | 1.00 | TDP1 (0.95) | TDP1GLAMAPTLMNAALDH1A1 | |
| Butenone SCHEMBL490740 | 1.00 | TDP1 (0.95) | TDP1GLAMAPTLMNAALDH1A1 | |
| Butenone SCHEMBL2891566 | 1.00 | TDP1 (0.95) | TDP1GLAMAPTLMNAALDH1A1 | |
| Butenone SCHEMBL5788285 | 1.00 | TDP1 (0.95) | TDP1GLAMAPTLMNAALDH1A1 | |
| Butenone SCHEMBL699144 | 1.00 | TDP1 (0.95) | TDP1GLAMAPTLMNAALDH1A1 | |
| Butenone SCHEMBL29739250 | 1.00 | TDP1 (0.95) | TDP1GLAMAPTLMNAALDH1A1 | |
| Butenone SCHEMBL4306181 | 1.00 | TDP1 (0.95) | TDP1GLAMAPTLMNAALDH1A1 | |
| Butenone SCHEMBL7053850 | 1.00 | TDP1 (0.95) | TDP1GLAMAPTLMNAALDH1A1 | |
| Butenone SCHEMBL12984182 | 0.98 | TDP1 (1.00) | TDP1GLAMAPTLMNAALDH1A1 | |
| Butenone SCHEMBL76632 | 0.98 | TDP1 (1.00) | TDP1GLAMAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878691-B2 | 6-11 bicyclic ketolide derivatives | ENANTA PHARMACEUTICALS, INC. (US) | 2005-04-12 | — | — | US | disclosed |