Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 3/20 | 0.40 |
| ▸ | CTSK | P43235 | 3/20 | 0.40 |
| ▸ | CTSV | O60911 | 2/20 | 0.40 |
| ▸ | CTSB | P07858 | 2/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6402488 | 1.00 | RAB9A (0.43) | RAB9AALDH1A1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL5632096 | 0.93 | RAB9A (0.49) | RAB9AALDH1A1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL5632091 | 0.93 | RAB9A (0.49) | RAB9AALDH1A1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL6614087 | 0.80 | RAB9A (0.46) | RAB9AALDH1A1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL8371338 | 0.79 | CTSK (0.48) | ALDH1A1LMNASMN1; SMN2NPC1MAPT | |
| SCHEMBL6403448 | 0.77 | CYP19A1 (0.40) | ALDH1A1LMNASMN1; SMN2HTTCYP2C9 | |
| SCHEMBL6403444 | 0.77 | CYP19A1 (0.40) | ALDH1A1LMNASMN1; SMN2HTTCYP2C9 | |
| SCHEMBL6404198 | 0.77 | CTSK (0.49) | RAB9ASMN1; SMN2MAPTCTSSCTSK | |
| SCHEMBL5631657 | 0.77 | CTSK (0.49) | RAB9ASMN1; SMN2MAPTCTSSCTSK | |
| SCHEMBL5631408 | 0.77 | CTSK (0.49) | RAB9ASMN1; SMN2MAPTCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107616-A1 | Alpha-ketoamide derivatives as cathepsin k inhibitors | SMITHKLINE BEECHAM CORPORATION | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107616-A1 | Alpha-ketoamide derivatives as cathepsin k inhibitors | CTSK, CTSE, CTSZ | RAB9A 1009/4885ALDH1A1 2900/4885LMNA 736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.