SCHEMBL6402673

SCHEMBL6402673

COc1ccc2c(C(=O)c3c[nH]c4ccccc34)cccc2c1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.63
TP53 P04637 1/20 0.63
NPSR1 Q6W5P4 1/20 0.63
GPR84 Q9NQS5 1/20 0.56
TUBB1 Q9H4B7 2/20 0.55
CNR2 P34972 3/20 0.54
CDC25B P30305 1/20 0.53
MAPT P10636 2/20 0.53
MEN1 O00255 1/20 0.53
NPC1 O15118 1/20 0.53
RAB9A P51151 1/20 0.53
KMT2A Q03164 1/20 0.53
GABRP O00591 2/20 0.52
GABRD O14764 2/20 0.52
GABRA1 P14867 2/20 0.52
GABRB1 P18505 2/20 0.52
GABRG2 P18507 2/20 0.52
GABRB3 P28472 2/20 0.52
GABRA5 P31644 2/20 0.52
GABRA3 P34903 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6402031 0.90 SMN1; SMN2 (0.63) SMN1; SMN2TP53NPSR1GPR84TUBB1
SCHEMBL11903896 0.89 NR4A2 (0.60) SMN1; SMN2TP53NPSR1GPR84TUBB1
SCHEMBL13302221 0.84 NPSR1 (0.72) SMN1; SMN2TP53NPSR1GPR84TUBB1
SCHEMBL29489280 0.83 GPR84 (0.77) SMN1; SMN2TP53NPSR1GPR84CNR2
SCHEMBL8530849 0.83 GPR84 (0.77) SMN1; SMN2TP53NPSR1GPR84CNR2
SCHEMBL6331990 0.81 PDGFRB (0.72) MEN1KMT2APDGFRBPDGFRAFLT3
SCHEMBL8792509 0.80 SMN1; SMN2 (0.73) SMN1; SMN2TP53NPSR1GPR84TUBB1
SCHEMBL8534922 0.78 SMN1; SMN2 (1.00) SMN1; SMN2TP53NPSR1GPR84TUBB1
SCHEMBL27908679 0.77 NR4A2 (0.77) SMN1; SMN2TP53NPSR1GPR84TUBB1
SCHEMBL10648347 0.76 CTNNB1 (0.72) SMN1; SMN2TP53NPSR1GPR84MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050009903-A1 CB2-selective cannabinoid analogues CLEMSON UNIVERSITY 2005-01-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050009903-A1 CB2-selective cannabinoid analogues CNR2, CNR1, GPR68 SMN1; SMN2 3412/4885TP53 1379/4885NPSR1 98/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.