Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 8/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6405134 | 1.00 | PTGS2 (0.46) | PTGS2MAPTSMN1; SMN2KDM4EHTT | |
| SCHEMBL6410068 | 1.00 | PTGS2 (0.46) | PTGS2MAPTSMN1; SMN2KDM4EHTT | |
| SCHEMBL6404227 | 0.89 | MAPT (0.41) | PTGS2MAPTSMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL6403759 | 0.89 | MAPT (0.41) | PTGS2MAPTSMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL6403764 | 0.89 | MAPT (0.41) | PTGS2MAPTSMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL6402677 | 0.83 | MAPT (0.41) | MAPTSMN1; SMN2KDM4ETDP1ALDH1A1 | |
| SCHEMBL6402682 | 0.83 | MAPT (0.41) | MAPTSMN1; SMN2KDM4ETDP1ALDH1A1 | |
| SCHEMBL6403478 | 0.83 | MAPT (0.38) | MAPTSMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL6403481 | 0.83 | MAPT (0.38) | MAPTSMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL6408786 | 0.82 | MAPT (0.37) | MAPTSMN1; SMN2KDM4EPOLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107616-A1 | Alpha-ketoamide derivatives as cathepsin k inhibitors | SMITHKLINE BEECHAM CORPORATION | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107616-A1 | Alpha-ketoamide derivatives as cathepsin k inhibitors | CTSK, CTSE, CTSZ | PTGS2 2149/4885MAPT 3643/4885SMN1; SMN2 4636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.