Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT known ✓ | P43490 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | LGMN | Q99538 | 2/20 | 0.37 |
| ▸ | SUV39H2 | Q9H5I1 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | F9 | P00740 | 1/20 | 0.34 |
| ▸ | ME3 | Q16798 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2127242 | 1.00 | MTNR1A (0.41) | MTNR1AMTNR1BGAARAD52LGMN | |
| SCHEMBL2126032 | 0.99 | MTNR1A (0.41) | MTNR1AMTNR1BGAARAD52LGMN | |
| Hydrochloric Acid SCHEMBL2128027 | 0.88 | NAMPT (0.41) | MTNR1AMTNR1BLMNASMN1; SMN2NAMPT | |
| SCHEMBL2126877 | 0.87 | NAMPT (0.41) | MTNR1AMTNR1BSUV39H2LMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6415215 | 0.79 | GAA (0.46) | GAARAD52LMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5707967 | 0.79 | GAA (0.46) | GAARAD52LMNASMN1; SMN2 | |
| SCHEMBL5707960 | 0.78 | GAA (0.47) | GAARAD52LMNASMN1; SMN2 | |
| SCHEMBL6152146 | 0.78 | GAA (0.47) | GAARAD52LMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5707927 | 0.76 | GAA (0.43) | GAARAD52LMNASMN1; SMN2PIK3CD | |
| Hydrochloric Acid SCHEMBL2535075 | 0.74 | GAA (0.38) | GAARAD52LGMNSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050257329-A1 | Composition for dyeing keratin fibers, comprising at least one alcohol oxidase and at least one cationic oxidation base, and process using this composition | L'OREAL S.A. (FR) | 2005-11-24 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050257329-A1 | Composition for dyeing keratin fibers, comprising at least one alcohol oxidase and at least one cationic oxidation base, and process using this composition | KRT18, ADH1C, ADH1A | NAMPT 862/4885MTNR1A 3525/4885MTNR1B 3354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.