Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | CTSG | P08311 | 1/20 | 0.32 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.32 |
| ▸ | CMA1 | P23946 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 2/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4908342 | 0.75 | CTSK (0.37) | NPSR1CTSSCTSLCNR2CTSK | |
| SCHEMBL4897207 | 0.75 | NPSR1 (0.37) | SMN1; SMN2NPSR1CTSSCTSLCNR2 | |
| SCHEMBL5636940 | 0.74 | CTSL (0.42) | CTSSCTSLCNR2CTSK | |
| SCHEMBL5636936 | 0.74 | CTSL (0.42) | CTSSCTSLCNR2CTSK | |
| SCHEMBL6403135 | 0.74 | CTSK (0.43) | ALDH1A1MEN1KMT2ASMN1; SMN2CTSS | |
| SCHEMBL6403132 | 0.74 | CTSK (0.43) | ALDH1A1MEN1KMT2ASMN1; SMN2CTSS | |
| SCHEMBL4908428 | 0.74 | CTSK (0.38) | NPSR1CTSSCTSLCNR2CTSK | |
| SCHEMBL6405369 | 0.73 | CTSK (0.45) | ALDH1A1MAPK1MEN1MAPTKMT2A | |
| SCHEMBL6406252 | 0.73 | CTSK (0.45) | ALDH1A1MAPK1MEN1MAPTKMT2A | |
| SCHEMBL6405372 | 0.73 | CTSK (0.45) | ALDH1A1MAPK1MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107616-A1 | Alpha-ketoamide derivatives as cathepsin k inhibitors | SMITHKLINE BEECHAM CORPORATION | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107616-A1 | Alpha-ketoamide derivatives as cathepsin k inhibitors | CTSK, CTSE, CTSZ | L3MBTL1 1689/4885ALDH1A1 2900/4885LMNA 736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.