Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 8/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.49 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.49 |
| ▸ | PRKX | P51817 | 1/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.49 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.49 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.49 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6405064 | 0.95 | AVPR1A (0.49) | AVPR1AKCNH2ROCK2PRKACARPS6KB1 | |
| SCHEMBL4963772 | 0.95 | TRPA1 (0.53) | AVPR1AKCNH2ROCK2PRKACARPS6KB1 | |
| SCHEMBL6405946 | 0.84 | AVPR1A (0.48) | AVPR1AKCNH2HDAC4ALDH1A1SMN1; SMN2 | |
| SCHEMBL6406749 | 0.84 | AVPR1A (0.48) | AVPR1AKCNH2HDAC4ALDH1A1SMN1; SMN2 | |
| SCHEMBL5049115 | 0.82 | AVPR1A (0.57) | AVPR1AKCNH2HDAC4ALDH1A1SMN1; SMN2 | |
| SCHEMBL6406056 | 0.81 | HDAC4 (0.47) | AVPR1AKCNH2HDAC4ALDH1A1SMN1; SMN2 | |
| SCHEMBL6405767 | 0.80 | TRPA1 (0.49) | AVPR1AKCNH2ALDH1A1SMN1; SMN2OXTR | |
| SCHEMBL6407406 | 0.80 | CYP3A4 (0.47) | AVPR1AKCNH2HDAC4ALDH1A1SMN1; SMN2 | |
| SCHEMBL6407775 | 0.79 | DRD4 (0.52) | HDAC4LMNA | |
| SCHEMBL4966313 | 0.78 | HDAC4 (0.49) | AVPR1AKCNH2HDAC4ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050288338-A1 | Amido compounds and their use as pharmaceuticals | INCYTE CORPORATION | 2005-12-29 | — | — | US | claimed |
| US-20050288338-A1 | Amido compounds and their use as pharmaceuticals | INCYTE CORPORATION | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288338-A1 | Amido compounds and their use as pharmaceuticals | HSD11B1, CYP11B1, HSD11B2 | AVPR1A 57/4885KCNH2 2120/4885ROCK2 2066/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.