Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 7/20 | 0.68 |
| ▸ | PGR | P06401 | 6/20 | 0.68 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.68 |
| ▸ | AR | P10275 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17603224 | 1.00 | NR3C1 (0.68) | NR3C1PGRNR3C2ARALDH1A1 | |
| SCHEMBL3274555 | 1.00 | NR3C1 (0.68) | NR3C1PGRNR3C2ARALDH1A1 | |
| SCHEMBL3279049 | 1.00 | NR3C1 (0.68) | NR3C1PGRNR3C2ARALDH1A1 | |
| SCHEMBL14437808 | 1.00 | NR3C1 (0.68) | NR3C1PGRNR3C2ARALDH1A1 | |
| SCHEMBL10942668 | 0.94 | NR3C1 (0.60) | NR3C1PGRNR3C2ARALDH1A1 | |
| SCHEMBL10942681 | 0.94 | NR3C1 (0.60) | NR3C1PGRNR3C2ARALDH1A1 | |
| SCHEMBL3275715 | 0.93 | NR3C1 (0.68) | NR3C1PGRNR3C2ARALDH1A1 | |
| SCHEMBL6408534 | 0.93 | NR3C1 (0.68) | NR3C1PGRNR3C2ARALDH1A1 | |
| SCHEMBL4982380 | 0.93 | NR3C1 (0.68) | NR3C1PGRNR3C2ARALDH1A1 | |
| SCHEMBL4979442 | 0.93 | NR3C1 (0.68) | NR3C1PGRNR3C2ARALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050215537-A1 | Epoxy-steroidal aldosterone antagonist and beta-adrenergic antagonist combination therapy for treatment of congestive heart failure | PHARMACIA CORPORATION | 2005-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215537-A1 | Epoxy-steroidal aldosterone antagonist and beta-adrenergic antagonist combination therapy for treatment of congestive heart failure | ADRB1, ADRB2, ADRB3 | NR3C1 32/4885PGR 338/4885NR3C2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.