Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | ITK | Q08881 | 6/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | CASP3 | P42574 | 2/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28405187 | 0.85 | PARP1 (0.52) | GSK3BRAB9ANPC1CYP19A1PARP1 | |
| SCHEMBL28401656 | 0.79 | KDM4E (0.51) | GSK3BRAB9ANPC1CYP19A1PARP1 | |
| SCHEMBL4778168 | 0.77 | GSK3B (0.38) | GSK3BRAB9ANPC1CYP19A1ITK | |
| SCHEMBL7194941 | 0.74 | RAB9A (0.47) | GSK3BRAB9ANPC1CYP19A1PARP1 | |
| SCHEMBL29542671 | 0.72 | CDC7 (0.46) | GSK3BCYP19A1PARP1ITKCYP2C19 | |
| SCHEMBL29542476 | 0.72 | CDC7 (0.46) | GSK3BCYP19A1PARP1ITKCYP2C19 | |
| SCHEMBL29631691 | 0.69 | RAB9A (0.74) | GSK3BRAB9ANPC1CYP19A1ITK | |
| SCHEMBL374022 | 0.69 | RAB9A (0.74) | GSK3BRAB9ANPC1CYP19A1ITK | |
| SCHEMBL2489128 | 0.69 | ITK (0.57) | GSK3BRAB9ANPC1CYP19A1PARP1 | |
| SCHEMBL5179280 | 0.69 | ITK (0.61) | GSK3BRAB9ANPC1CYP19A1ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6841685-B2 | Methods for making bis-heterocyclic alkaloids | STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF OREGON STATE UNIVERSITY (US) | 2005-01-11 | — | — | US | disclosed |
| US-20030232988-A1 | Methods for making bis-heterocyclic alkaloids | STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF OREGON STATE UNIVERSITY,THE | 2003-12-18 | — | — | US | disclosed |
| WO-2001094310-A1 | METHODS FOR MAKING BIS-HETEROCYCLIC ALKALOIDS | THE STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF OREGON STATE UNIVERSITY (US) | 2001-12-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030232988-A1 | Methods for making bis-heterocyclic alkaloids | CIAPIN1, AAAS, MDN1 | GSK3B 1455/4885RAB9A 3868/4885NPC1 4290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.