SCHEMBL6406843

SCHEMBL6406843

N=C(NO)c1ccc(OC(F)F)cc1

nearest known ligand 0.62

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ ALOX15 P16050 1/20 0.62
▸ GFER P55789 1/20 0.62
▸ ADAM17 P78536 1/20 0.62
▸ ATM Q13315 1/20 0.46
▸ ALDH1A1 P00352 5/20 0.42
▸ POLB P06746 3/20 0.41
▸ KDM4E B2RXH2 2/20 0.41
▸ MAPT P10636 2/20 0.41
▸ HTT P42858 2/20 0.40
▸ PKM P14618 1/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.40
▸ GAA P10253 2/20 0.40
▸ LMNA P02545 1/20 0.39
▸ MEN1 O00255 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ DRD1 P21728 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17055827 0.81 KMT2A (0.53) ALOX15GFERADAM17ALDH1A1POLB
SCHEMBL24665314 0.81 ALOX15 (0.43) ALOX15GFERADAM17KDM4ELMNA
SCHEMBL17064043 0.79 RAB9A (0.50) ALOX15GFERADAM17ATMPOLB
SCHEMBL21740372 0.76 ALOX15 (0.52) ALOX15GFERADAM17ATMALDH1A1
SCHEMBL12348299 0.76 HSD17B10 (0.36) ALOX15ALDH1A1LMNA
SCHEMBL23578113 0.75 ACACB (0.40) ALOX15GFERADAM17MAPTHTT
SCHEMBL23578547 0.75 ACACB (0.40) ALOX15GFERADAM17MAPTHTT
SCHEMBL23578115 0.75 ACACB (0.40) ALOX15GFERADAM17MAPTHTT
Hydrochloric Acid SCHEMBL9060564 0.74 ST14 (0.57) ALOX15GFERADAM17
SCHEMBL8716162 0.74 TAS1R3 (0.38) ALOX15GFERADAM17KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6841661-B2 Glycopeptide antibacterial compounds, compositions containing same and methods of using same PRINCETON UNIVERISITY (US) 2005-01-11 — — US claimed
US-20030224975-A1 Glycopeptide antibacterial compounds, compositions containing same and methods of using same PRINCETON UNIVERSITY (US) 2003-12-04 — — US claimed
US-6498238-B1 Glycopeptide antibacterial compounds, compositions containing same and methods of using same PRINCETON UNIVERSITY 2002-12-24 — — US claimed
EP-4463452-B1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER ANIMA BIOTECH INC (US) 2025-07-30 — — EP disclosed
US-12344600-B2 c-Myc mRNA translation modulators and uses thereof in the treatment of cancer ANIMA BIOTECH INC. (US) 2025-07-01 — — US disclosed
US-20250109128-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER ANIMA BIOTECH INC. (US) 2025-04-03 — — US disclosed
EP-4463452-A2 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER Anima Biotech Inc. (US) 2024-11-20 — — EP disclosed
WO-2023177700-A2 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER ANIMA BIOTECH INC. (US) 2023-09-21 — — WO disclosed
EP-3275440-B1 NOVEL OXADIAZOLE DERIVATIVE AND PHARMACEUTICAL CONTAINING SAME NAT CT GERIATRICS & GERONTOLOGY (JP) 2022-05-04 — — EP disclosed
US-20180072708-A1 NOVEL OXADIAZOLE DERIVATIVE AND PHARMACEUTICAL CONTAINING SAME NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY (JP) 2018-03-15 — — US disclosed
US-20180072708-A1 NOVEL OXADIAZOLE DERIVATIVE AND PHARMACEUTICAL CONTAINING SAME NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY (JP) 2018-03-15 — — US disclosed
WO-2014031928-A2 HETEROCYCLIC MODULATORS OF HIF ACTIVITY FOR TREATMENT OF DISEASE JONES PHILIP (US) 2014-02-27 — — WO disclosed
EP-1423120-A4 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF ICOS CORP (US) 2005-12-28 — — EP disclosed
US-6924284-B2 PARP inhibitors ICOS CORPORATION (US) 2005-08-02 — — US disclosed
US-6841661-B2 Glycopeptide antibacterial compounds, compositions containing same and methods of using same PRINCETON UNIVERISITY (US) 2005-01-11 — — US disclosed
EP-1423120-A1 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF ICOS CORPORATION (US) 2004-06-02 — — EP disclosed
US-20040087588-A1 Parp inhibitors ICOS CORPORATION 2004-05-06 — — US disclosed
US-20030224975-A1 Glycopeptide antibacterial compounds, compositions containing same and methods of using same PRINCETON UNIVERSITY (US) 2003-12-04 — — US disclosed
WO-2003015785-A1 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF ICOS CORPORATION (US) 2003-02-27 — — WO disclosed
US-6498238-B1 Glycopeptide antibacterial compounds, compositions containing same and methods of using same PRINCETON UNIVERSITY 2002-12-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030224975-A1 Glycopeptide antibacterial compounds, compositions containing same and methods of using same FUT6, GALNT6, UGCG ALOX15 1880/4885GFER 413/4885ADAM17 1981/4885
US-20040087588-A1 Parp inhibitors PARP1, PARP2, PARP11 ALOX15 1940/4885GFER 3595/4885ADAM17 1357/4885
US-12344600-B2 c-Myc mRNA translation modulators and uses thereof in the treatment of cancer MYC, MYCBP, MYCBP2 ALOX15 3870/4885GFER 4267/4885ADAM17 4344/4885
US-20250109128-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER MYC, MYCBP, MYCBP2 ALOX15 3870/4885GFER 4267/4885ADAM17 4344/4885
US-20180072708-A1 NOVEL OXADIAZOLE DERIVATIVE AND PHARMACEUTICAL CONTAINING SAME APP, BACE1, PSEN1 ALOX15 1146/4885GFER 251/4885ADAM17 683/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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