Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6410153 | 0.84 | KDM4E (0.43) | L3MBTL1KDM4EALDH1A1PKMCTSD | |
| SCHEMBL6341574 | 0.77 | MEN1 (0.56) | L3MBTL1ALDH1A1KMT2AMEN1TDP1 | |
| SCHEMBL6403530 | 0.75 | ALDH1A1 (0.49) | KDM4EALDH1A1CTSDKMT2APOLB | |
| SCHEMBL6407647 | 0.73 | PI4KB (0.34) | L3MBTL1KDM4EALDH1A1PKMCTSD | |
| SCHEMBL6408514 | 0.73 | KDM4E (0.36) | L3MBTL1KDM4EALDH1A1PKMCTSD | |
| SCHEMBL6410968 | 0.73 | RORC (0.37) | L3MBTL1KDM4EALDH1A1PKMKMT2A | |
| SCHEMBL6410963 | 0.73 | RORC (0.37) | L3MBTL1KDM4EALDH1A1PKMKMT2A | |
| SCHEMBL6407652 | 0.73 | L3MBTL1 (0.32) | L3MBTL1KDM4EALDH1A1CTSDKMT2A | |
| SCHEMBL6405533 | 0.72 | PKM (0.37) | L3MBTL1KDM4EALDH1A1PKMKMT2A | |
| SCHEMBL6405526 | 0.72 | PKM (0.37) | L3MBTL1KDM4EALDH1A1PKMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6969713-B2 | Piperidine and piperazine acetamide derivatives | ASTRAZENECA AB (SE) | 2005-11-29 | — | — | US | disclosed |
| EP-1242427-B1 | NOVEL PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2003-08-13 | — | — | EP | disclosed |
| US-20030013721-A1 | Novel piperidine and piperazine derivatives | ASTRAZENECA AB (SE) | 2003-01-16 | — | — | US | disclosed |
| EP-1242427-A1 | NOVEL PIPERIDINE AND PIPERAZINE DERIVATIVES | AstraZeneca AB (SE) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001046200-A1 | NOVEL PIPERIDINE AND PIPERAZINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030013721-A1 | Novel piperidine and piperazine derivatives | IL5, VIP, EP300 | L3MBTL1 4881/4885KDM4E 1566/4885ALDH1A1 68/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.