Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | CBX7 | O95931 | 1/20 | 0.40 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.40 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.40 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 4/20 | 0.37 |
| ▸ | MAT2A | P31153 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL641034 | 0.86 | NPEPPS (0.43) | DAOAURKAMEN1LMNAKMT2A | |
| SCHEMBL638525 | 0.85 | PGR (0.38) | AURKAL3MBTL1PGRGRIN2DGRIN3B | |
| SCHEMBL640118 | 0.79 | AURKA (0.49) | DAOAURKACBX7CDYL2CDYL | |
| SCHEMBL640147 | 0.73 | PPARG (0.45) | MEN1KMT2APPARG | |
| SCHEMBL641065 | 0.70 | MEN1 (0.60) | MEN1LMNAKMT2AL3MBTL1PGR | |
| SCHEMBL8886284 | 0.67 | MEN1 (0.77) | DAOAURKAMEN1LMNAKMT2A | |
| SCHEMBL8883239 | 0.67 | KMT2A (0.63) | DAOAURKAMEN1LMNAKMT2A | |
| SCHEMBL31743953 | 0.67 | MEN1 (0.77) | DAOAURKAMEN1LMNAKMT2A | |
| SCHEMBL20844646 | 0.67 | KEAP1 (0.46) | MEN1LMNAKMT2AL3MBTL1SIRT1 | |
| SCHEMBL640677 | 0.66 | HSP90AA1 (0.44) | MEN1LMNAKMT2AL3MBTL1GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119676-B2 | Substituted benzimidazolone derivatives, medicaments comprising them and their use | Abbott GmbH & Co. HG (DE) | 2012-02-21 | — | — | US | disclosed |