Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.54 |
| ▸ | PARP1 | P09874 | 14/20 | 0.53 |
| ▸ | TNK1 | Q13470 | 10/20 | 0.52 |
| ▸ | TNK2 | Q07912 | 6/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | DRD5 | P21918 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6411449 | 0.99 | DRD2 (0.53) | DRD2PARP1TNK1TNK2KCNH2 | |
| SCHEMBL6405680 | 0.89 | PARP1 (0.64) | PARP1TNK1TNK2KCNH2PARP2 | |
| SCHEMBL6403556 | 0.81 | PARP1 (0.49) | PARP1TNK1TNK2KCNH2PARP2 | |
| Hydrochloric Acid SCHEMBL6403678 | 0.80 | PARP1 (0.55) | PARP1KCNH2PARP2HTR1ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL6403655 | 0.76 | PARP1 (0.60) | PARP1KCNH2PARP2SIGMAR1 | |
| Hydrochloric Acid SCHEMBL6406350 | 0.74 | PARP1 (0.79) | PARP1TNK1TNK2KCNH2PARP2 | |
| SCHEMBL6407854 | 0.74 | PARP1 (0.51) | PARP1TNK1TNK2KCNH2PARP2 | |
| SCHEMBL6556204 | 0.73 | PARP1 (0.53) | PARP1TNK1TNK2KCNH2PARP2 | |
| SCHEMBL6406366 | 0.72 | PARP1 (0.62) | DRD2PARP1TNK1TNK2KCNH2 | |
| SCHEMBL25822114 | 0.72 | PARP1 (0.74) | PARP1TNK1TNK2KCNH2PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487800-A1 | PHENANTHRIDINONES AS PARP INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003080581-A1 | PHENANTHRIDINONES AS PARP INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-10-02 | — | — | WO | disclosed |