Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SCN1A | P35498 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28884650 | 0.88 | KEAP1 (0.46) | KEAP1SMN1; SMN2HPGDDUSP3SIGMAR1 | |
| SCHEMBL619185 | 0.78 | KEAP1 (0.40) | KEAP1SMN1; SMN2HPGDDUSP3SIGMAR1 | |
| SCHEMBL646006 | 0.77 | KEAP1 (0.39) | KEAP1SMN1; SMN2HPGDDUSP3SIGMAR1 | |
| SCHEMBL4526655 | 0.77 | KEAP1 (0.48) | KEAP1SMN1; SMN2HPGDDUSP3SIGMAR1 | |
| SCHEMBL231271 | 0.75 | KEAP1 (0.60) | KEAP1SMN1; SMN2HPGDDUSP3SIGMAR1 | |
| SCHEMBL17092603 | 0.74 | KMT2A (0.35) | HPGDALDH1A1RAB9ALMNA | |
| SCHEMBL232859 | 0.73 | KEAP1 (0.58) | KEAP1SMN1; SMN2HPGDDUSP3SIGMAR1 | |
| SCHEMBL5241352 | 0.72 | ALDH1A1 (0.38) | SMN1; SMN2ALDH1A1KDM4EHRH3LMNA | |
| SCHEMBL233216 | 0.71 | KEAP1 (0.56) | KEAP1SMN1; SMN2HPGDDUSP3SIGMAR1 | |
| SCHEMBL10889066 | 0.71 | KEAP1 (0.56) | KEAP1SMN1; SMN2HPGDDUSP3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050014773-A1 | Therapeutic use | ASTRAZENACA AB (SE) | 2005-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014773-A1 | Therapeutic use | CD4, HLA-DRB1, CD74 | KEAP1 3355/4885SMN1; SMN2 2546/4885HPGD 1735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.