Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | PNMT | P11086 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | NOS3 | P29474 | 2/20 | 0.36 |
| ▸ | NOS1 | P29475 | 2/20 | 0.36 |
| ▸ | NOS2 | P35228 | 2/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29473237 | 1.00 | DPP4 (0.54) | DPP4ADRB2LOXL2CASP6PNMT | |
| SCHEMBL17794539 | 0.82 | DPP4 (0.58) | DPP4LOXL2PNMTALDH1A1NOS3 | |
| Hydrochloric Acid SCHEMBL28773304 | 0.82 | HRH1 (0.47) | DPP4ADRB2CASP6CYP1A2CYP2D6 | |
| SCHEMBL3790206 | 0.79 | KDM4E (0.50) | DPP4LOXL2CYP1A2ALDH1A1KDM4E | |
| SCHEMBL29496884 | 0.79 | KDM4E (0.50) | DPP4LOXL2CYP1A2ALDH1A1KDM4E | |
| SCHEMBL23082861 | 0.78 | CYP2D6 (0.44) | CASP6CYP1A2CYP2D6ALDH1A1KDM4E | |
| SCHEMBL28294207 | 0.78 | CASP6 (0.47) | DPP4CASP6CYP1A2CYP2D6ALDH1A1 | |
| SCHEMBL3787333 | 0.78 | DPP4 (0.73) | DPP4LOXL2PNMTNOS3NOS1 | |
| SCHEMBL28966789 | 0.77 | CASP6 (0.42) | DPP4CASP6CYP1A2CYP2D6ALDH1A1 | |
| SCHEMBL16814935 | 0.76 | DPP4 (0.51) | DPP4LOXL2PNMTNOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220119395-A1 | BICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2022-04-21 | — | — | US | disclosed |
| CN-105461699-B | Substituted heterocyclic compound and its application method and purposes | 广东东阳光药业有限公司 | 2019-07-09 | — | — | CN | disclosed |
| CN-103467386-B | Aryl pyrimidine ortho-position monocyano compounds and synthesis method thereof | UNIV SHANGHAI | 2015-05-27 | — | — | CN | disclosed |
| CN-103467386-A | Aryl pyrimidine ortho-position monocyano compounds and synthesis method thereof | UNIV SHANGHAI | 2013-12-25 | — | — | CN | disclosed |
| CN-101585814-B | Aryl pyrimidine ortho-single halogen substituted compound and synthetic method thereof | UNIV SHANGHAI SCIENCE & TECH | 2011-08-10 | — | — | CN | disclosed |
| CN-101585814-A | Aryl pyrimidine ortho-single halogen substituted compound and synthetic method thereof | UNIV SHANGHAI SCIENCE & TECH (CN) | 2009-11-25 | — | — | CN | disclosed |
| US-20050171131-A1 | Diaminopyrimidine derivatives as growth hormone secrectgogue receptor (GHS-R) antagonists | KOSOGOF CHRISTI (US) | 2005-08-04 | — | — | US | disclosed |
| US-20050070712-A1 | Pyrimidine derivatives as ghrelin receptor modulators | ABBOTT LABORATORIES | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220119395-A1 | BICYCLIC COMPOUNDS | SLC10A1, PKD1, CYP11B2 | DPP4 651/4885ADRB2 480/4885LOXL2 3562/4885 |
| US-20050171131-A1 | Diaminopyrimidine derivatives as growth hormone secrectgogue receptor (GHS-R) antagonists | GHSR, GIPR, GPR119 | DPP4 127/4885ADRB2 1999/4885LOXL2 4172/4885 |
| US-20050070712-A1 | Pyrimidine derivatives as ghrelin receptor modulators | GPR119, GIPR, GCGR | DPP4 372/4885ADRB2 1047/4885LOXL2 4447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.