Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIB | P23284 | 1/20 | 0.31 |
| ▸ | PPIA | P62937 | 1/20 | 0.31 |
| ▸ | PPID | Q08752 | 1/20 | 0.31 |
| ▸ | PPIG | Q13427 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 2/20 | 0.31 |
| ▸ | ACACB | O00763 | 5/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6403241 | 0.72 | TBXA2R (0.38) | TP53CNR2MEN1ALDH1A1MAPT | |
| SCHEMBL6403516 | 0.72 | TBXA2R (0.38) | TP53CNR2MEN1ALDH1A1MAPT | |
| SCHEMBL6605887 | 0.72 | KDM4E (0.35) | TP53HSD17B10KDM4EALDH1A1MAPT | |
| SCHEMBL6409426 | 0.72 | KDM4E (0.35) | TP53HSD17B10KDM4EALDH1A1MAPT | |
| SCHEMBL6408016 | 0.72 | KDM4E (0.35) | TP53HSD17B10KDM4EALDH1A1MAPT | |
| SCHEMBL6409487 | 0.68 | TP53 (0.31) | TP53HSD17B10NPC1USP2RAB9A | |
| SCHEMBL6606317 | 0.66 | KDM4E (0.38) | TP53HSD17B10KDM4EMEN1ALDH1A1 | |
| SCHEMBL8371644 | 0.65 | ESR1 (0.35) | HSD17B10KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL2370973 | 0.55 | MMP8 (0.59) | PPIBPPIAPPIDPPIGHSD17B10 | |
| SCHEMBL15059305 | 0.54 | EPHX2 (0.44) | PPIBPPIAPPIDPPIGHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107616-A1 | Alpha-ketoamide derivatives as cathepsin k inhibitors | SMITHKLINE BEECHAM CORPORATION | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107616-A1 | Alpha-ketoamide derivatives as cathepsin k inhibitors | CTSK, CTSE, CTSZ | PPIB 918/4885PPIA 688/4885PPID 977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.