Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6411483 | 0.99 | LMNA (0.46) | LMNANPSR1HTR1AHTR1DHTR2B | |
| SCHEMBL5410651 | 0.89 | LMNA (0.43) | LMNANPSR1KMT2AMEN1RIPK1 | |
| SCHEMBL6410259 | 0.88 | HTR2B (0.53) | LMNAHTR1AHTR1DHTR2BCCR5 | |
| SCHEMBL6409590 | 0.88 | LMNA (0.42) | LMNANPSR1RIPK1CCR5HSD11B1 | |
| SCHEMBL6411432 | 0.88 | CCR2 (0.50) | LMNAHTR1AHTR1DHTR2BCCR5 | |
| Hydrochloric Acid SCHEMBL6411467 | 0.88 | HTR2B (0.52) | LMNAHTR1AHTR1DHTR2BCCR5 | |
| Hydrochloric Acid SCHEMBL6415620 | 0.87 | CCR2 (0.49) | LMNAHTR1AHTR1DHTR2BCCR5 | |
| Hydrochloric Acid SCHEMBL6409168 | 0.87 | LMNA (0.41) | LMNANPSR1RIPK1CCR5HSD11B1 | |
| SCHEMBL6415519 | 0.85 | CTSB (0.39) | LMNANPSR1RIPK1CCR5HSD11B1 | |
| SCHEMBL6409366 | 0.85 | HSD11B1 (0.40) | LMNANPSR1HTR1AHTR1DHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | VIROCHEM PHARMA INC (CA) | 2005-04-07 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | CXCR1, CXCR4, CXCR2 | LMNA 3107/4885NPSR1 48/4885HTR1A 1039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.