Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 4/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.50 |
| ▸ | USP2 | O75604 | 5/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CCR2 | P41597 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5863917 | 0.78 | SIGMAR1 (0.61) | OPRL1OPRM1ALDH1A1KCNA3MEN1 | |
| SCHEMBL4130505 | 0.76 | TSHR (0.82) | OPRL1USP2CYP2C9ALDH1A1CYP2C19 | |
| SCHEMBL22477399 | 0.75 | TSHR (0.51) | USP2CYP2C9ALDH1A1CYP2C19TSHR | |
| SCHEMBL6769513 | 0.73 | ALDH1A1 (0.56) | OPRL1OPRM1ALDH1A1KCNA3MEN1 | |
| SCHEMBL6412380 | 0.72 | OPRL1 (0.53) | OPRL1OPRM1USP2CYP2C9ALDH1A1 | |
| SCHEMBL14027003 | 0.71 | TSHR (0.73) | USP2CYP2C9ALDH1A1CYP2C19TSHR | |
| Prozapine SCHEMBL25765 | 0.71 | ALDH1A1 (0.66) | OPRL1ALDH1A1KCNA3CYP2D6CCR2 | |
| Fenpiprane SCHEMBL24507 | 0.71 | ALDH1A1 (0.66) | OPRL1ALDH1A1KCNA3CYP2D6CCR2 | |
| SCHEMBL1426593 | 0.71 | CYP2D6 (0.84) | USP2CYP2C9ALDH1A1CYP2C19TSHR | |
| SCHEMBL23135107 | 0.70 | TSHR (0.61) | USP2CYP2C9ALDH1A1CYP2C19TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | VIROCHEM PHARMA INC (CA) | 2005-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | CXCR1, CXCR4, CXCR2 | OPRL1 151/4885OPRM1 244/4885USP2 4697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.