Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 7/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.48 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MLNR | O43193 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3647086 | 0.77 | LTA4H (0.61) | OPRL1OPRM1ALDH1A1CYP2D6OPRD1 | |
| SCHEMBL13964192 | 0.74 | OPRL1 (0.74) | OPRL1OPRM1CYP2D6OPRD1OPRK1 | |
| SCHEMBL10263099 | 0.73 | OTUD7B (0.45) | MTORLTA4H | |
| SCHEMBL6408789 | 0.73 | CCR3 (0.55) | OPRL1OPRM1KCNA3CYP2D6LMNA | |
| SCHEMBL6836359 | 0.73 | SIGMAR1 (0.70) | OPRL1DRD2HTR2AHTR2CADRA1A | |
| SCHEMBL5863917 | 0.73 | SIGMAR1 (0.61) | OPRL1OPRM1KCNA3ALDH1A1CYP2D6 | |
| SCHEMBL6409592 | 0.72 | OPRL1 (0.56) | OPRL1OPRM1KCNA3ALDH1A1CYP2D6 | |
| Hydrochloric Acid SCHEMBL6412282 | 0.72 | CCR3 (0.54) | OPRL1OPRM1KCNA3CYP2D6LMNA | |
| SCHEMBL6408850 | 0.72 | CCR2 (0.60) | OPRL1OPRM1KCNA3ALDH1A1CYP2D6 | |
| SCHEMBL6703717 | 0.71 | KCNA3 (0.58) | OPRL1OPRM1KCNA3ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | VIROCHEM PHARMA INC (CA) | 2005-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | CXCR1, CXCR4, CXCR2 | OPRL1 151/4885OPRM1 244/4885KCNA3 2165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.